Successful minimal invasive treatment of chylous ascites following pancreaticoduodenectomy: A case report and review of literature. (June 2021)

• Record Type: Journal Article
• Authors: Nguyen, Thanh Khiem; Luong, Tuan Hiep; Nguyen, Ngoc Cuong; Nguyen, Ham Hoi; Nguyen, Ngoc Hung; Trinh, Hong Son
• Is Part Of: Annals of medicine and surgery. Volume 66(2021)
• Publication Date: 2021-06
• Subjects: Pancreatic cancer -- Lymphadenectomy -- Chylous ascites -- Pancreaticoduodenectomy -- Postoperative lymphatic leakage -- Case report; Surgery -- Periodicals; Medicine -- Periodicals; General Surgery -- Periodicals; Education, Medical -- Periodicals; Periodicals; 617
• DOI: 10.1016/j.amsu.2021.102451
• Languages: English
• ISSNs: 2049-0801

Abstract

Abstract: Introduction: Chylous ascites is an uncommon but potentially life-threatening type of postoperative lymphatic leakage, especially following pancreaticoduodenectomy. Case presentation: A 59-year-old man underwent pancreaticoduodenectomy (PD) with extended lymphadenectomy and segmental Superior Mesenteric Vein (SMV) resection for SMV-involved pancreatic ductal adenocarcinoma (PDAC). After 20th postoperative day, patient had a drain output with a milky appearance, and with a triglyceride level was 1.6 mmol/L, and the daily output volume was up to 1500 mL per day. She has been performed Conventional Lymphangiography (CLAG) to identify the broken lymphatic vessels as well as close the leakage. Following two consecutive lymphangiography, the source of chylous leakage was identified from hilar lymphatic system, and injection of Aetoxisclerol 2% into lymphatic vessels to close the leakage was performed. Partial parenteral nutrition with limited fat components or medium-chain triglyceride (MCT) was administered, and the amount of ascites decreased particularly. The drain was removed in 20th day after the second CLAG. He had no symptoms of abdominal distention after drain removal and had been discharged after 37 postoperative days (PODs). Discussion: Chylous ascites is an uncommon but potentially life-threatening complication following pancreaticoduodenectomy. Portal lymphatic plexus, which was often isolated and dissected especially with extended lymphadenectomy, is potentially damaged and caused resistant chylous leakage. Newly techniques are updated and applied in diagnosis and treatment for this difficult-to-treat complication, one of them is percutaneous transhepatic Conventional Lymphangiography (CLAG). Conclusion: CLAG with percutaneous transhepatic access could be effective to identify and terminate the chylous fistula from portal lymphatic plexus after pancreaticoduodenectomy. Highlights: Chylous ascites is a potentially life-threatening type of lymphatic leakage, following pancreaticoduodenectomy. Portal lymphatic plexus was a potential location of lymphatic fistula due to the regularity of isolation and dissection in pancreaticoduodenectomy with extended lymphadenectomy. Conventional Lymphangiography (CLAG) is an invasion to identify the broken lymphatic vessels and close the leakage. Percutaneous transhepatic CLAG is a technique to puncture the portal lymphatic vessels, which could not be approached with other methods.