Diabetes emergencies around Ramadan study (DEARS) – A multi-center study of diabetes emergencies admitted before, during and after Ramadan in Malaysia. (May 2021)

• Record Type: Journal Article
• Authors: Tong, Chin Voon; Yow, Hui Yin; Mohd Noor, Nurain; Hussein, Zanariah
• Is Part Of: Diabetes research and clinical practice. Volume 175(2021)
• Publication Date: 2021-05
• Subjects: Diabetes -- Fasting -- Hypoglycemia -- Diabetes ketoacidosis -- Hyperosmolar hyperglycemic state; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2021.108854
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: It is a multi-center study done in a majority Muslim country with high number of patients who fast during Ramadan. Admissions for Hyperglycemic Hyperosmolar State during Ramadan were also specifically studied in addition to Diabetes Ketoacidosis and hypoglycemia. Limitations include lack of baseline HbA1c to assess control of disease. This was only done in one country. Abstract: Objective: The objective of this study was to determine admissions for diabetes emergencies among patients who fasted or planned to fast one month before, during and one month after Ramadan 2019 in public hospitals in Malaysia. Materials and methods: This was a cross sectional prospective study done in 18 public hospitals in Malaysia from 7/4/2019 to 2/7/2019. Data was collected prospectively with universal sampling. All adult Muslim patients with previous diagnosis of diabetes, who were admitted for hypoglycemia, DKA or HHS were included if they had fasted and had intentions to fast. Results: 295 admissions for diabetes emergencies were analyzed. The pre-Ramadan period recorded the highest number of admissions (119) followed by during (106) and post-Ramadan (70). Admissions for hyperglycemic emergencies accounted for 2/3 of total admissions. 37% of admissions for hypoglycemia occurred during pre-Ramadan period compared to 32.1% during Ramadan. Contributing factors included use of sulphonylurea (59.6%), presence of nephropathy (54.5%) and past history of hypoglycemia (45.5%). Admissions for DKA were more common than HHS (119 versus 77) and highest during Ramadan period (36.1%). Most of the admissions for hyperglycemic emergencies were among those with Type 2 diabetes (75.9% for DKA and 97.4% for HHS). Only 31.5% of patients admitted for diabetes emergencies recalled having received Ramadan advice in the past. Discussion: Admissions for diabetes emergencies were highest during pre-Ramadan period followed by Ramadan and post-Ramadan period. This suggests that fasting during Ramadan does not increase admissions for diabetes emergencies.