A suite of neurophotonic tools to underpin the contribution of internal brain states in fMRI. (June 2021)

• Record Type: Journal Article
• Authors: Mächler, Philipp; Broggini, Thomas; Mateo, Celine; Thunemann, Martin; Fomin-Thunemann, Natalie; Doran, Patrick R.; Sencan, Ikbal; Kilic, Kivilcim; Desjardins, Michèle; Uhlirova, Hana; Yaseen, Mohammad A.; Boas, David A.; Linninger, Andreas A.; Vergassola, Massimo; Yu, Xin; Lewis, Laura D.; Polimeni, Jonathan R.; Rosen, Bruce R.; Sakadžić, Sava; Buxton, Richard B.; Lauritzen, Martin; Kleinfeld, David; Devor, Anna
• Is Part Of: Current opinion in biomedical engineering. Volume 18(2021)
• Publication Date: 2021-06
• Subjects: Neuromodulation -- Optical imaging -- Hemodynamic -- CMRO2 -- Glycolysis; Biomedical engineering -- Periodicals; 610.28
• DOI: 10.1016/j.cobme.2021.100273
• Languages: English
• ISSNs: 2468-4511

Abstract

Abstract: Recent developments in optical microscopy, applicable for large-scale and longitudinal imaging of cortical activity in behaving animals, open unprecedented opportunities to gain a deeper understanding of neurovascular and neurometabolic coupling during different brain states. Future studies will leverage these tools to deliver foundational knowledge about brain state-dependent regulation of cerebral blood flow and metabolism, as well as regulation as a function of brain maturation and aging. This knowledge is of critical importance to interpret hemodynamic signals observed with functional magnetic resonance imaging (fMRI). Highlights: Optical probes for neuromodulation may allow direct measurements of cortical states. Relative contribution of oxidative and glycolytic metabolism to hemodynamics may be state-dependent. Loss of aerobic glycolysis in aging may be related to weakening of neuromodulation. Neuromodulation can alter vasomotion oscillations, a measure of brain state observed through fMRI.