Bio-based nanomaterials for cancer therapy. (June 2021)

• Record Type: Journal Article
• Authors: Li, Yonglu; Zheng, Xiaodong; Chu, Qiang
• Is Part Of: Nano today. Volume 38(2021)
• Publication Date: 2021-06
• Subjects: Bioactive substance -- Nanomaterials -- Cancer therapy -- Tumor targeting -- Biosafety; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2021.101134
• Languages: English
• ISSNs: 1748-0132

Abstract

Highlights: This review summarizes the oncological application of bio-based nanomaterials. The structure, property, and biological performance of nano-systems are exemplified. The challenges and perspectives of bio-based nanomaterials in oncotherapy are discussed. Graphical Abstract: The schematic image to illustrate the six types of bioactive substances that this review focused on. ga1 Abstract: Bio-based nanomaterials have received considerable attention in cancer therapies due to their potent characteristics such as autologous pharmaceutical, synergetic effects, biocompatibility, biodegradability and biosafety. Here, we took breast cancer (BC) for example, mainly focused on six types of bioactive substances (nucleic acid, phenolics, polysaccharides, protein and peptide, lipid and cell) and their applications in bio-based nano-formulation for oncological therapies. Particularly, we have categorized the functions of these bioactive substances and exemplified the nano-systems' composite constructions, structural characterizations, versatile properties, anti-tumor mechanisms and biological performances. Ultimately, we thoroughly discussed the present challenges and future perspectives in the emerging research frontier. We believe that this review would offer inspired ideas, promising strategies and potential pathways for designing state-of-the-bio-based-nanomaterials for cancer therapy in critical and advanced biomedical sciences.