The extracellular matrix: A key player in the pathogenesis of hematologic malignancies. (July 2021)

• Record Type: Journal Article
• Authors: Sidhu, Ishnoor; Barwe, Sonali P.; Gopalakrishnapillai, Anilkumar
• Is Part Of: Blood reviews. Volume 48(2021)
• Publication Date: 2021-07
• Subjects: Extracellular matrix -- Matricellular proteins -- Hematological malignancies -- Bone marrow niche -- Adhesion -- Chemoresistance; AML Acute myeloid leukemia -- Ara-C Cytarabine -- ATL Adult T-cell leukemia -- B-ALL B-cell acute lymphocytic leukemia -- B-CLL B-cell chronic lymphocytic leukemia -- BCP-ALL B cell precursor ALL -- BM Bone marrow -- BMF Bone marrow fibrosis -- BTD Bortezomib, thalidomide and dexamethasone -- CCL2 C-C motif chemokine ligand 2 -- CCL3 C-C motif chemokine ligand 3 -- CLL Chronic lymphocytic leukemia -- CML Chronic myeloid leukemia -- CNS Central nervous system -- CS Chondroitin sulfate -- CSPG Chondroitin sulfate proteoglycan -- CTCL Cutaneous T-cell lymphoma -- CTL Cytotoxic T lymphocytes -- DDR Discoidin domain receptors -- DLBCL Diffuse large B-cell lymphoma -- DS Dermatan sulfate -- ECM Extracellular matrix -- EGFR Epidermal growth factor receptor -- ERK Extracellular regulated kinase -- FAK Focal adhesion kinase -- GAG Glycosaminoglycan -- GM-CSF Granulocyte and monocyte-colony stimulating factor -- HA Hyaluronan -- HGF Hepatocyte growth factor -- HL Hodgkin's lymphoma -- HMs Hematological malignancies -- HS Heparan sulfate -- HSCs Hematopoietic stem cells -- HSPCs Hematopoietic stem and progenitor cells -- HSPG Proteoglycan with heparan sulfate side chain -- JAK Janus kinase -- KS Keratan sulfate -- LOX Lysyl oxidase -- MAPK Mitogen activated protein kinase -- MDS Myelodysplastic syndrome -- MGUS Monoclonal gammopathy of undetermined significance (precursor to MM) -- MM Multiple myeloma -- MMP Matrix metalloproteinases, plasmin -- MRD Minimal residual disease -- MSCs Mesenchymal stromal/stem cells -- NHL Non-Hodgkin's lymphoma -- NF-κB Nuclear factor kappa B -- NPM1 Nucleophosmin 1 -- Opn Osteopontin -- PG Proteoglycan -- PRELP Proline/arginine-rich end leucine-rich repeat protein -- SLRP Small leucine-rich proteoglycan -- SPARC Secreted protein, acidic and rich in cysteine -- STAT Signal transducer and activator of transcription -- T-ALL T-cell acute lymphoblastic leukemia -- TGF-β Transforming growth factor-β -- Tsp-1 Thrombospondin-1 -- VEGF Vascular endothelial growth factor; Hematology -- Periodicals; Hematology -- Periodicals; Hématologie -- Périodiques; Hematology; Electronic journals; Periodicals; 616.15
• DOI: 10.1016/j.blre.2020.100787
• Languages: English
• ISSNs: 0268-960X

Abstract

Abstract: Hematopoietic stem and progenitor cells located in the bone marrow lay the foundation for multiple lineages of mature hematologic cells. Bone marrow niches are architecturally complex with specific cellular, physiochemical, and biomechanical factors. Increasing evidence suggests that the bone marrow microenvironment contributes to the pathogenesis of hematological neoplasms. Numerous studies have deciphered the role of genetic mutations and chromosomal translocations in the development hematologic malignancies. Significant progress has also been made in understanding how the cellular components and cytokine interactions within the bone marrow microenvironment promote the evolution of hematologic cancers. Although the extracellular matrix is known to be a key player in the pathogenesis of various diseases, it's role in the progression of hematologic malignancies is less understood. In this review, we discuss the interactions between the extracellular matrix and malignant cells, and provide an overview of the role of extracellular matrix remodeling in sustaining hematologic malignancies.