Diagnosis and treatment of lymphomas in the era of epigenetics. (July 2021)

• Record Type: Journal Article
• Authors: Chebly, Alain; Chouery, Eliane; Ropio, Joana; Kourie, Hampig Raphael; Beylot-Barry, Marie; Merlio, Jean-Philippe; Tomb, Roland; Chevret, Edith
• Is Part Of: Blood reviews. Volume 48(2021)
• Publication Date: 2021-07
• Subjects: Lymphoma -- Epigenetics -- DNA methylation -- Histone modification -- miRNA -- Epigenetic therapy; ABC-DLBCL Activated B-cell like diffuse large B-cell lymphoma -- AITL Angioimmunoblastic T-cell lymphoma -- ALCL Anaplastic large-cell lymphoma -- ATLL Adult T-cell leukemia/lymphoma -- C-ALCL Cutaneous anaplastic large-cell lymphoma -- BL Burkitt lymphoma -- CBCL Cutaneous B-cell lymphoma -- CLL Chronic lymphocytic leukemia -- CTCL Cutaneous T-cell lymphoma -- DLBCL Diffuse large B-cell lymphoma -- DNMT DNA methyltransferase -- DNMTi DNA methyltransferase inhibitors -- FL Follicular lymphoma -- GC-DLBCL Germinal center B-cell like diffuse large B-cell lymphoma -- HAT Histone acetyltransferases -- HDAC Histone deacetylases -- HDACi HDAC inhibitors -- HL Hodgkin lymphoma -- HMT Histone methyltransferases -- HMTi Histone methyltransferases inhibitors -- IDH Isocitrate dehydrogenase -- KAT Lysine acetyltransferases -- KDM Lysine demethylases -- MCL Mantle cell Lymphoma -- KMT Lysine methyltransferases -- MF Mycosis fungoides -- MFt Mycosis fungoides tumor stage -- NGS Next-generation sequencing -- NHLs Non hodgkin lymphomas -- PCLBCL-LT Primary cutaneous diffuse large B-cell lymphoma- Leg type -- PCFCL Primary cutaneous follicle center lymphoma -- PMBCL Primary mediastinal B-cell lymphoma -- PRC2 Polycomb repressive complex 2 -- PTCL Peripheral T-cell lymphpma -- SLL Small lymphocytic lymphoma -- SS Sézary syndrome -- TET Ten-eleven translocation -- tFL Transformed follicular lymphoma; Hematology -- Periodicals; Hematology -- Periodicals; Hématologie -- Périodiques; Hematology; Electronic journals; Periodicals; 616.15
• DOI: 10.1016/j.blre.2020.100782
• Languages: English
• ISSNs: 0268-960X

Abstract

Abstract: Lymphomas represent a heterogeneous group of cancers characterized by clonal lymphoproliferation. Over the past decades, frequent epigenetic dysregulations have been identified in hematologic malignancies including lymphomas. Many of these impairments occur in genes with established roles and well-known functions in the regulation and maintenance of the epigenome. In hematopoietic cells, these dysfunctions can result in abnormal DNA methylation, erroneous chromatin state and/or altered miRNA expression, affecting many different cellular functions. Nowadays, it is evident that epigenetic dysregulations in lymphoid neoplasms are mainly caused by genetic alterations in genes encoding for enzymes responsible for histone or chromatin modifications. We summarize herein the recent epigenetic modifiers findings in lymphomas. We focus also on the most commonly mutated epigenetic regulators and emphasize on actual epigenetic therapies.