Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia. (July 2021)

• Record Type: Journal Article
• Authors: Hamilton, Shanna; Terentyeva, Radmila; Clements, Richard T.; Belevych, Andriy E.; Terentyev, Dmitry
• Is Part Of: Journal of molecular and cellular cardiology. Volume 156(2021)
• Page Start: 105
• Page End: 113
• Publication Date: 2021-07
• Subjects: Sarcoplasmic reticulum -- Mitochondria -- Calcium signaling -- Cardiac arrhythmia; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2021.04.002
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to malignant cardiac arrhythmias. Both defective mitochondrial function and abnormal intracellular Ca 2+ homeostasis have been established as the key contributing factors in the pathophysiology and arrhythmogenesis in these conditions. This article reviews current advances in understanding of bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca 2+ release and mitochondrial function, and how defects in crosstalk between these two organelles increase arrhythmic risk in cardiac disease. Graphical abstract: Unlabelled Image