Emissive radiodense stealth plasmonic nanohybrid as X-ray contrast and photo-ablative agent of cancer cells. (June 2021)

• Record Type: Journal Article
• Authors: Mehta, Jinal M.; Jain, Nishant K.; Chauhan, Deepak S.; Prasad, Rajendra; Kumawat, Mukesh K.; Dhanka, Mukesh; Shanavas, Asifkhan; Srivastava, Rohit
• Is Part Of: Materials today communications. Volume 27(2021)
• Publication Date: 2021-06
• Subjects: Nanohybrid -- Gold nanoparticles -- Hyaluronic acid -- Graphene quantum dots -- Multimode imaging; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2021.102181
• Languages: English
• ISSNs: 2352-4928

Abstract

Graphical abstract: Highlights: Synthesis of biodegradable and biocompatible plasmonic nanohybrid for cancer theranostics. Designed HA-GQD_AuPLGA NS (H-Photofluor) exhibits tunable absorption in NIR range. GQDs enabled fluorescence imaging for identifying tumor site. HA coating helps in active targeting of H-Photofluor selectively towards CD44 receptors. Efficient thermal ablation using 750 nm NIR laser studied in MDA-MB-231 cells. Abstract: Biodegradation and site-selective theranostic ability are critical concerns in cancer nanomedicine. Herein, we report a biodegradable plasmonic nanohybrid called H-PhotoFluor towards augmenting the dynamic contrast ability, focalized tumor imaging, and efficient ablation of cancer cells. Integrated hyaluronic acid (HA) targeting ligand, gold nanoshells, and fluorescent graphene quantum dots (GQDs) induce the multimodality in engineered nanohybrid. The ridges of deposited gold nanoparticles help in the efficient binding of HA that augments the entrapment of GQDs. The active targeting here is achieved with the help of HA coating that selectively targets CD44 receptors. The pivotal element in focused imaging is attained by GQDs. These photothermally active radiodense engineered H-PhotoFluor (∼140 nm) have been tested for targeted tumor imaging and site-selective cancer cell destruction. Hemocompatibility, biocompatibility, biodegradability, photothermal activity and cellular internalization of H-PhotoFluor have been studied systematically. The observed outcomes of the aforementioned studies make H-PhotoFluor, a clinically relevant nanotheranostic agent.