Design concepts for DNA-encoded library synthesis. (1st July 2021)

• Record Type: Journal Article
• Authors: Zhang, Y.; Clark, M.A.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 41(2021)
• Publication Date: 2021-07-01
• Subjects: DNA-Encoded Library -- Medicinal Chemistry; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2021.116189
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade's worth of DEL-driven screening.