Point-of-care diagnostics approaches for detection of lung cancer-associated circulating miRNAs. Issue 6 (June 2021)

• Record Type: Journal Article
• Authors: Shandilya, Ruchita; Ranjan, Shashi; Khare, Surbhi; Bhargava, Arpit; Goryacheva, Irina Yu; Mishra, Pradyumna Kumar
• Is Part Of: Drug discovery today. Volume 26:Issue 6(2021)
• Page Start: 1501
• Page End: 1509
• Publication Date: 2021-06
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2021.02.023
• Languages: English
• ISSNs: 1359-6446

Abstract

Graphical abstract: Highlights: Circulating microRNAs offer great potential for diagnosis of the stage and type of lung cancer. The review outlines various point-of-care (POC) approaches for miRNA detection. Nanomaterial based paper, chip, array, film and smartphone POC approaches are discussed. Abstract : Circulating cell-free miRNAs (ccf-miRs) have gained significant interest as biomarkers for lung cancer (LC) diagnosis. However, the clinical application of ccf-miRs is mainly limited by time, cost, and expertise-related problems of existing detection strategies. Recently, the development of different point-of-care (POC) approaches offers useful on-site platforms, because these technologies have important features such as portability, rapid turnaround time, minimal sample requirement, and cost-effectiveness. In this review, we discuss different POC approaches for detecting ccf-miRs and highlight the utility of incorporating nanomaterials for enhanced biorecognition and signal transduction, further improving their diagnostic applicability in LC settings.