Comparison of ICC patients with hepatitis B infection to those with no major risk factors for HCC. Issue 6 (June 2021)

• Record Type: Journal Article
• Authors: Kim, Kwang Min; Na, Ji Eun; Shim, Sang Goon; Sinn, Dong Hyun
• Is Part Of: HPB. Volume 23:Issue 6(2021)
• Page Start: 945
• Page End: 953
• Publication Date: 2021-06
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1016/j.hpb.2020.10.011
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: Background: There has been renewed interest in HBV-associated ICC, because it could share a common carcinogenesis disease process with HCC. We investigated whether there is a difference in clinical outcome between ICC patients with HBV infection and those without any major risk factors for HCC. Methods: A total of 253 curatively resected, surgically diagnosed ICC patients were analyzed and divided into two groups according to the presence or absence of major risk factors for HCC: an HBV group (n = 45) and a non–HCC–risk (NHR) group (n = 208). Results: Lymph node metastasis was more frequently observed in the NHR group (HBV vs. NHR: 8.89% vs. 24.52%, P = 0.027). Patients in the HBV group demonstrated more favorable survival than those in the NHR group. However, this difference was not statistically significant (5-year survival rate, 54.7% vs. 42.3%, P = 0.128). Cumulative recurrence rate in the HBV group was 62.2%, which was not significantly different from 63.0% in the NHR group ( P = 1.000). Conclusion: This study found that while ICC patients with HBV infection showed some favorable tumor characteristics, patients' stage-specific survival and recurrence rates were not significantly different compared to those without any major risk factors for HCC.