Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry. Issue 7 (27th January 2021)

• Record Type: Journal Article
• Authors: Strangfeld, Anja; Schäfer, Martin; Gianfrancesco, Milena A; Lawson-Tovey, Saskia; Liew, Jean W; Ljung, Lotta; Mateus, Elsa F; Richez, Christophe; Santos, Maria J; Schmajuk, Gabriela; Scirè, Carlo A; Sirotich, Emily; Sparks, Jeffrey A; Sufka, Paul; Thomas, Thierry; Trupin, Laura; Wallace, Zachary S; Al-Adely, Sarah; Bachiller-Corral, Javier; Bhana, Suleman; Cacoub, Patrice; Carmona, Loreto; Costello, Ruth; Costello, Wendy; Gossec, Laure; Grainger, Rebecca; Hachulla, Eric; Hasseli, Rebecca; Hausmann, Jonathan S; Hyrich, Kimme L; Izadi, Zara; Jacobsohn, Lindsay; Katz, Patricia; Kearsley-Fleet, Lianne; Robinson, Philip C; Yazdany, Jinoos; Machado, Pedro M;
• Other Names: author non-byline.; Dahou Brahim author non-byline.; Pinheiro Marcelo author non-byline.; Ribeiro Francinne M author non-byline.; Chassin-Trubert Anne-Marie author non-byline.; Ibáñez Sebastián author non-byline.; Dong Lingli author non-byline.; Cajas Lui author non-byline.; Hamoud Hesham author non-byline.; Avouac Jérôme author non-byline.; Belin Véronique author non-byline.; Borie Raphaël author non-byline.; Chazerain Pascal author non-byline.; Chevalier Xavier author non-byline.; Claudepierre Pascal author non-byline.; Clavel Gaëlle author non-byline.; Colette-Cedoz Marie-Eve author non-byline.; Combe Bernard author non-byline.; Constant Elodie author non-byline.; Costedoat-Chalumeau Nathalie author non-byline.; Desmurs Marie author non-byline.; Devauchelle-Pensec Valérie author non-byline.; Devaux Mathilde author non-byline.; Dhote Robin author non-byline.; Dieudonné Yannick author non-byline.; Domont Fanny author non-byline.; Duret Pierre-Marie author non-byline.; Ebbo Mikaël author non-byline.; Ebstein Esther author non-byline.; Mahou Soumaya El author non-byline.; Fautrel Bruno author non-byline.; Felten Renaud author non-byline.; Flipo René-Marc author non-byline.; Foltz Violaine author non-byline.; Froissart Antoine author non-byline.; Galland Joris author non-byline.; Gaud-Listrat Véronique author non-byline.; Georgin-Lavialle Sophie author non-byline.; Giraud-Morelet Aude author non-byline.; Quitrec Jeanine S Giraudet-Le author non-byline.; Goupille Philippe author non-byline.; Govindaraju-Audouard Sophie author non-byline.; Grados Franck author non-byline.; Guillaume-Czitrom Séverine author non-byline.; Hermet Marion author non-byline.; Hittinger-Roux Ambre author non-byline.; Hudry Christophe author non-byline.; Kone-Paut Isabelle author non-byline.; Alanore Sylvain La Batide author non-byline.; Lafforgue Pierre author non-byline.; Lahalle Sophie author non-byline.; Lambrecht Isabelle author non-byline.; Langlois Vincent author non-byline.; Larbre Jean-Paul author non-byline.; Ledoult Emmanuel author non-byline.; Leroux Christophe author non-byline.; Liote Frédéric author non-byline.; Maria Alexandre TJ author non-byline.; Marotte Hubert author non-byline.; Mekinian Arsène author non-byline.; Melki Isabelle author non-byline.; Messer Laurent author non-byline.; Michel Catherine author non-byline.; Morel Gauthier author non-byline.; Morel Jacques author non-byline.; Paris-Havard Marie-Noelle author non-byline.; Pertuiset Edouard author non-byline.; Pham Thao author non-byline.; Renard Myriam author non-byline.; Revuz Sabine author non-byline.; Rivière Sébastien author non-byline.; Rousselin Clémentine author non-byline.; Roux Christian author non-byline.; Rouzaud Diane author non-byline.; Sellam Jérémie author non-byline.; Seror Raphaele author non-byline.; Servettaz Amelie author non-byline.; Sobanski Vincent author non-byline.; Sordet Christelle author non-byline.; Spielmann Lionnel author non-byline.; Tieulié Nathalie author non-byline.; Tison Alice author non-byline.; Trijau Sophie author non-byline.; Virone Alexandre author non-byline.; Warzocha Ursula author non-byline.; Wendling Daniel author non-byline.; Albach Frederik N author non-byline.; Aries Peer author non-byline.; Decker Elvira author non-byline.; Hartmann Urs author non-byline.; Henes Joerg author non-byline.; Hoyer Bimba F author non-byline.; Krause Andreas author non-byline.; Krüger Klaus author non-byline.; Lorenz Hanns-Martin author non-byline.; Müller-Ladner Ulf author non-byline.; Pfeil Alexander author non-byline.; Regierer Anne author non-byline.; Richter Jutta G author non-byline.; Rihl Markus author non-byline.; Schmeiser Tim author non-byline.; Schulze-Koops Hendrik author non-byline.; Specker Christof author non-byline.; Voll Reinhard E author non-byline.; Werner Stephanie author non-byline.; Melgar Gabriela MG author non-byline.; Vojdanian Mahdi author non-byline.; Andreoli Laura author non-byline.; Bartoloni-Bocci Elena author non-byline.; Benucci Maurizio author non-byline.; Campanaro Francesco author non-byline.; Caprioli Marta author non-byline.; Carboni Davide author non-byline.; Carrara Greta author non-byline.; Cipolletta Edoardo author non-byline.; Crotti Chiara author non-byline.; Dallagiacoma Gloria author non-byline.; Faggioli Paola author non-byline.; Foti Rosario author non-byline.; Franceschini Franco author non-byline.; Fredi Micaela author non-byline.; Guidelli Giacomo author non-byline.; Iannone Florenzo author non-byline.; Landolfi Gianpiero author non-byline.; Lomater Caludia author non-byline.; Nalli Ceciclia author non-byline.; Parisi Simone author non-byline.; Quartuccio Luca author non-byline.; Raffeiner Bernd author non-byline.; Reggia Rossella author non-byline.; Riva Marta author non-byline.; Romeo Nicoletta author non-byline.; Rotondo Cinzia author non-byline.; Silvagni Ettore author non-byline.; Sinigaglia Luigi author non-byline.; Tinazzi Ilaria author non-byline.; Zanetti Anna author non-byline.; Zanframundo Giovanni author non-byline.; Abutiban Fatemah author non-byline.; Alpízar-Rodríguez Deshiré author non-byline.; Rull-Gabayet Marina author non-byline.; Irazoque Fedra author non-byline.; Jimenez Xochitl author non-byline.; Martín-Nares Eduardo author non-byline.; Castillo-Ortiz Angel author non-byline.; Rodriguez-Reyna Tatiana S author non-byline.; Rosete Diana C author non-byline.; Zamora-Tehozol Erick A author non-byline.; Vega-Morales David author non-byline.; Zaueta-Montiel Beatriz Elena author non-byline.; Al-Adhoubi Nasra author non-byline.; Salim Babur author non-byline.; Giraldo Enrique author non-byline.; Salinas Ariel author non-byline.; Ugarte-Gil Manuel author non-byline.; Almeida Diogo author non-byline.; Bernardes Miguel author non-byline.; Machado Rita C author non-byline.; Rato Maria author non-byline.; Al-Emadi Samar author non-byline.; Conway Richard author non-byline.; Flood Rachael author non-byline.; Alegre-Sancho Juan J author non-byline.; Coro Montserrat C author non-byline.; Torre-Rubio Natalia de la author non-byline.; Esteban Jose C author non-byline.; Martin Maria del author non-byline.; Puerta Jose G author non-byline.; Back Johan author non-byline.; Dastmalchi Maryam author non-byline.; Dupré Brigitte author non-byline.; Grenholm Emma author non-byline.; Hensvold Aase author non-byline.; Knight Ann author non-byline.; Akar Servet author non-byline.; Icacan Ozan C author non-byline.; Chadwick Laura author non-byline.; Devine Kirsty author non-byline.; Dunt Sasha author non-byline.; Fusi Lucia author non-byline.; Jones Caroline M author non-byline.; Macphie Elizabeth author non-byline.; Nikiphorou Elena author non-byline.; O'Kane Diana author non-byline.; O'Reilly Sheila author non-byline.; Patel Samir author non-byline.; Salerno Rosaria author non-byline.; Thornton Lucy author non-byline.; Tyler Jenny author non-byline.; Vandevelde Claire author non-byline.; Warner Elizabeth author non-byline.; Yeoh Su-Ann author non-byline.; Baig Sara author non-byline.; Bajwa Hammad author non-byline.; Ban Byung author non-byline.; Berglund Vernon author non-byline.; Calabrese Cassandra author non-byline.; D'Silva Kristin author non-byline.; Dahle Angela author non-byline.; Dao Kathryn author non-byline.; Daver Nicole author non-byline.; Davis William author non-byline.; Dorman Walter author non-byline.; Fatemeh Ezzati author non-byline.; Fields Theodore author non-byline.; Hargrove Jody author non-byline.; Harvey Melissa author non-byline.; Hilton Maren author non-byline.; Hsu Tiffany author non-byline.; Izadi Zara author non-byline.; Jayatilleke Arundathi author non-byline.; Karp David author non-byline.; Kepecs Gilbert author non-byline.; Kramer Neil author non-byline.; Lamore Concetta author non-byline.; Lebedoff Nicholas author non-byline.; Leonard Susan author non-byline.; Mody Sushama author non-byline.; Morgan Jennifer author non-byline.; Pfeifer Emily author non-byline.; Quiceno Guillermo author non-byline.; Quinet Robert author non-byline.; Rosenstein Elliot author non-byline.; Ruderman Eric author non-byline.; Scopelitis Evangeline author non-byline.; Serling-Boyd Naomi author non-byline.; Siddique Faizah author non-byline.; Skemp Archibald author non-byline.; Sparks Jeffrey author non-byline.; Todd Derrick author non-byline.; Toribio Karen T author non-byline.; Wallwork Rachel author non-byline.; Webb-Detiege Tameka author non-byline.; White Douglas author non-byline.; Wilson Jeffrey author non-byline.; Winter Melanie author non-byline.; Wise Leanna author non-byline.; Wolff Anne author non-byline.; Young Kristen author non-byline.; Zakem Jerald author non-byline.; Zell JoAnn author non-byline.; Zimmerman Kurt author non-byline.;
• Is Part Of: Annals of the rheumatic diseases. Volume 80:Issue 7(2021)
• Page Start: 930
• Page End: 942
• Publication Date: 2021-01-27
• Subjects: antirheumatic agents -- autoimmune diseases -- epidemiology -- glucocorticoids -- outcome assessment -- health care; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-219498
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To determine factors associated with COVID-19-related death in people with rheumatic diseases. Methods: Physician-reported registry of adults with rheumatic disease and confirmed or presumptive COVID-19 (from 24 March to 1 July 2020). The primary outcome was COVID-19-related death. Age, sex, smoking status, comorbidities, rheumatic disease diagnosis, disease activity and medications were included as covariates in multivariable logistic regression models. Analyses were further stratified according to rheumatic disease category. Results: Of 3729 patients (mean age 57 years, 68% female), 390 (10.5%) died. Independent factors associated with COVID-19-related death were age (66–75 years: OR 3.00, 95% CI 2.13 to 4.22; >75 years: 6.18, 4.47 to 8.53; both vs ≤65 years), male sex (1.46, 1.11 to 1.91), hypertension combined with cardiovascular disease (1.89, 1.31 to 2.73), chronic lung disease (1.68, 1.26 to 2.25) and prednisolone-equivalent dosage >10 mg/day (1.69, 1.18 to 2.41; vs no glucocorticoid intake). Moderate/high disease activity (vs remission/low disease activity) was associated with higher odds of death (1.87, 1.27 to 2.77). Rituximab (4.04, 2.32 to 7.03), sulfasalazine (3.60, 1.66 to 7.78), immunosuppressants (azathioprine, cyclophosphamide, ciclosporin, mycophenolate or tacrolimus: 2.22, 1.43 to 3.46) and not receiving any disease-modifying anti-rheumatic drug (DMARD) (2.11, 1.48 to 3.01) were associated with higher odds of death, compared with methotrexate monotherapy. Other synthetic/biological DMARDs were not associated with COVID-19-related death. Conclusion: Among people with rheumatic disease, COVID-19-related death was associated with known general factors (older age, male sex and specific comorbidities) and disease-specific factors (disease activity and specific medications). The association with moderate/high disease activity highlights the importance of adequate disease control with DMARDs, preferably without increasing glucocorticoid dosages. Caution may be required with rituximab, sulfasalazine and some immunosuppressants.