Type D personality is associated with depressive symptoms and clinical activity in inflammatory bowel disease. Issue 1 (11th May 2021)

• Record Type: Journal Article
• Authors: Jordi, Sebastian Bruno Ulrich; Botte, Federica; Lang, Brian Matthew; Greuter, Thomas; Krupka, Niklas; Auschra, Bianca; Schreiner, Philipp; Sulz, Michael Christian; Biedermann, Luc; von Känel, Roland; Rogler, Gerhard; Begré, Stefan; Misselwitz, Benjamin
• Other Names: Anderegg Claudia investigator.; Bauerfeind Peter investigator.; Beglinger Christoph investigator.; Belli Dominique investigator.; Bengoa José M. investigator.; Bigler Beat investigator.; Binek Janek investigator.; Blattmann Mirjam investigator.; Boehm Stephan investigator.; Borovicka Jan investigator.; Braegger Christian P. investigator.; Brunner Nora investigator.; Bühr Patrick investigator.; Burnand Bernard investigator.; Burri Emanuel investigator.; Buyse Sophie investigator.; Cremer Matthias investigator.; Criblez Dominique H. investigator.; de Saussure Philippe investigator.; Degen Lukas investigator.; Delarive Joakim investigator.; Doerig Christopher investigator.; Dora Barbara investigator.; Dorta Gian investigator.; Egger Mara investigator.; Ehmann Tobias investigator.; El‐Wafa Ali investigator.; Engelmann Matthias investigator.; Ezri Jessica investigator.; Felley Christian investigator.; Fliegner Markus investigator.; Fournier Nicolas investigator.; Fraga Montserrat investigator.; Frei Pascal investigator.; Frei Remus investigator.; Fried Michael investigator.; Froehlich Florian investigator.; Funk Christian investigator.; Furlano Raoul Ivano investigator.; Gallot‐Lavallée Suzanne investigator.; Geyer Martin investigator.; Girardin Marc investigator.; Golay Delphine investigator.; Grandinetti Tanja investigator.; Gysi Beat investigator.; Haack Horst investigator.; Haarer Johannes investigator.; Helbling Beat investigator.; Hengstler Peter investigator.; Herzog Denise investigator.; Hess Cyrill investigator.; Heyland Klaas investigator.; Hinterleitner Thomas investigator.; Hiroz Philippe investigator.; Hirschi Claudia investigator.; Hruz Petr investigator.; Iwata Rika investigator.; Jost Res investigator.; Juillerat Pascal investigator.; Brondolo Vera Kessler investigator.; Knellwolf Christina investigator.; Knoblauch Christoph investigator.; Köhler Henrik investigator.; Koller Rebekka investigator.; Krieger‐Grübel Claudia investigator.; Kullak‐Ublick Gerd investigator.; Künzler Patrizia investigator.; Landolt Markus investigator.; Lange Rupprecht investigator.; Lehmann Frank Serge investigator.; Macpherson Andrew investigator.; Maerten Philippe investigator.; Maillard Michel H. investigator.; Manser Christine investigator.; Manz Michael investigator.; Marbet Urs investigator.; Marx George investigator.; Matter Christoph investigator.; McLin Valérie investigator.; Meier Rémy investigator.; Mendanova Martina investigator.; Meyenberger Christa investigator.; Michetti Pierre investigator.; Moradpour Darius investigator.; Morell Bernhard investigator.; Mosler Patrick investigator.; Mottet Christian investigator.; Müller Christoph investigator.; Müller Pascal investigator.; Müllhaupt Beat investigator.; Münger‐Beyeler Claudia investigator.; Musso Leilla investigator.; Nagy Andreas investigator.; Neagu Michaela investigator.; Nichita Cristina investigator.; Niess Jan investigator.; Noël Natacha investigator.; Nydegger Andreas investigator.; Obialo Nicole investigator.; Oneta Carl investigator.; Oropesa Cassandra investigator.; Peter Ueli investigator.; Peternac Daniel investigator.; Petit Laetitia Marie investigator.; Piccoli‐Gfeller Franziska investigator.; Pilz Julia Beatrice investigator.; Pittet Valérie investigator.; Raschle Nadia investigator.; Rentsch Ronald investigator.; Restellini Sophie investigator.; Richterich Jean‐Pierre investigator.; Rihs Sylvia investigator.; Ritz Marc Alain investigator.; Roduit Jocelyn investigator.; Rogler Daniela investigator.; Rossel Jean‐Benoît investigator.; Sagmeister Markus investigator.; Saner Gaby investigator.; Sauter Bernhard investigator.; Sawatzki Mikael investigator.; Schäppi Michela investigator.; Scharl Michael investigator.; Schelling Martin investigator.; Schibli Susanne investigator.; Schlauri Hugo investigator.; Uebelhart Sybille Schmid investigator.; Schnegg Jean‐François investigator.; Schoepfer Alain investigator.; Seibold Frank investigator.; Seirafi Mariam investigator.; Semadeni Gian‐Marco investigator.; Semela David investigator.; Senning Arne investigator.; Sidler Marc investigator.; Sokollik Christiane investigator.; Spalinger Johannes investigator.; Spangenberger Holger investigator.; Stadler Philippe investigator.; Steuerwald Michael investigator.; Straumann Alex investigator.; Straumann‐Funk Bigna investigator.; Thorens Joël investigator.; Tiedemann Sarah investigator.; Tutuian Radu investigator.; Vavricka Stephan investigator.; Viani Francesco investigator.; Vögtlin Jürg investigator.; Vonlaufen Alain investigator.; Vouillamoz Dominique investigator.; Vulliamy Rachel investigator.; Wermuth Jürg investigator.; Werner Helene investigator.; Wiesel Paul investigator.; Wiest Reiner investigator.; Wylie Tina investigator.; Zeitz Jonas investigator.; Zimmermann Dorothee investigator.;
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 54:Issue 1(2021)
• Page Start: 53
• Page End: 67
• Publication Date: 2021-05-11
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.16365
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: Inflammatory bowel disease (IBD) can be exacerbated by stress and depression. Type D personality, characterised by high negative affectivity and social inhibition, represents a vulnerability towards stressors and is associated with adverse outcomes in coronary heart disease. Aims: To assess the prevalence of Type D personality in IBD patients and investigate potential associations with disease course. Methods: We tested for associations between Type D ( Type D Scale‐14 ), depressive symptoms ( Hospital Anxiety and Depression Scale's depression subscore ≥11) and recurrent IBD amongst Swiss IBD cohort patients. We built regression models for cross‐sectional and Cox proportional hazards models for time‐to‐event analyses. IBD disease course was assessed by the future occurrence of active disease ( Crohn's Disease Activity Index ≥150/ Modified Truelove & Witts activity index ≥10) and several IBD‐relevant endpoints. Results: Amongst 2275 patients (1005 ulcerative colitis, 1270 Crohn's disease), 672 (29.5%) had Type D. Type D was a significant risk factor for future active disease (adjusted hazard ratio, aHR: 1.60, corrected P value, q = 0.007) and predicted the future presence of depressive symptoms (aHR: 3.30, P < 0.001). The combination of Type D and depressive symptoms further increased the risk for active disease (aHR: 3.98, q < 0.001). However, Type D associated depressive symptoms seemed to be the main contributor to this effect as Type D's predictive power decreased considerably in models corrected for depressive symptoms (aHR: 1.32, CI: 0.97‐1.79, q = 0.292). Conclusions: Type D personality's prevalence amongst IBD patients was comparable with its prevalence in the general population. Type D was strongly associated with depressive symptoms and showed modest independent associations with IBD prognosis. Abstract : The prevalence of Type D personality among IBD patients was comparable to the general population. Type D personality was associated with future episodes of active disease and depressive symptoms. The combination of Type D personality and concomitant depressive symptoms further increased the hazard for future disease recurrence.