Copper‐mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide. (24th May 2021)

• Record Type: Journal Article
• Authors: Kondo, Yuto; Kimura, Hiroyuki; Fukumoto, Chiaki; Yagi, Yusuke; Hattori, Yasunao; Kawashima, Hidekazu; Yasui, Hiroyuki
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 64:Number 8(2021)
• Page Start: 336
• Page End: 345
• Publication Date: 2021-05-24
• Subjects: 125I -- aryl boronic precursor -- c(RGDyk) -- copper‐mediated -- cyclic peptide -- radioiodination -- αVβ3 integrin inhibitor; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3925
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : A copper‐mediated radioiodination using aryl boronic precursors is attracting attention as a solution to oxidative iododestannylation and nickel‐mediated radioiodination drawbacks. The copper‐mediated radiolabeling method allows radioiodination at room temperature with stable aryl boronic precursors without preparing complex starting materials or reagents and can be performed in a reaction vessel exposed to air. This method has good potential in radiochemistry; however, studies on the scope of copper‐mediated radioiodination through boronic precursors are insufficient. In particular, few reports have demonstrated the effect of protecting groups on radiolabeling efficiency. Therefore, the effect of the protecting group of aryl boronic acids on the copper‐mediated radioiodination was investigated. In addition, this method, which does not require heating, is expected to be useful for direct radiolabeling of peptides. Thus, we attempted direct radioiodination of c(RGDyk) as an example. The resulting radioiodination method was well tolerated in various substrates and was unaffected by the pinacol ester‐type protecting group. Also, c(RGDyk) was labeled with 125 I via copper‐mediated radioiodination using an aryl boronic acid precursor. The reaction time and yield were improved, compared with the indirect method. Furthermore, the large difference in polarity between the boronic acid precursor and the radiolabeled compound facilitated purification. Abstract : A copper‐mediated radioiodination using aryl boronic precursors was well tolerated in various substrates and was unaffected by the pinacol ester‐type protecting group. Also, this radioiodination was an effective method to achieve direct radioiodination of c(RGDyk), a cyclic peptide.