Spatial Genomics: Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows (Small 23/2021). Issue 23 (10th June 2021)

• Record Type: Journal Article
• Authors: Voith von Voithenberg, Lena; Kashyap, Aditya; Opitz, Lennart; Aquino, Catharine; Sykes, Timothy; Nieser, Maike; Petrini, Lorenzo F. T.; Enrriquez Casimiro, Nadia; van Kooten, Xander F.; Biskup, Saskia; Schlapbach, Ralph; Schraml, Peter; Kaigala, Govind V.
• Is Part Of: Small. Volume 17:Issue 23(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-10
• Subjects: microfluidic probe -- next generation sequencing -- spatial genomics -- tumor heterogeneity; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202170112
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : The GeneScape workflow, presented in article number 2007901 by Govind V. Kaigala and co‐workers, uses a modular multipurpose microfluidic probe to facilitate evaluation of spatial genomic heterogeneity in tumors. Cancer cells essentially contain the same genomic blueprint but accumulate distinct corruptions at different spatial and temporal coordinates. Since these cells reside in several interacting ecosystems, it becomes very critical to study the spatial mutational landscape to evaluate and quantify tumor progression.