In-vitro Degradation Behaviors of Poly(L-lactide-co-glycolide-co-ε-caprolactone) Microspheres. Issue 7 (3rd July 2021)

• Record Type: Journal Article
• Authors: Yi, Meiling; Zhou, Zhihua; Liu, Wenjuan; Huang, Tianlong; Zhao, Yanmin; Chen, Ping; Zhou, Ziwei; Wang, Dan; Zhang, Chao; Fang, Jianjun
• Is Part Of: Journal of macromolecular science. Volume 60:Issue 7(2021)
• Page Start: 521
• Page End: 529
• Publication Date: 2021-07-03
• Subjects: degradation behavior -- microspheres -- poly(L-lactide-co-glycolide-co-ε-caprolactone); Polymerization -- Periodicals; Polymers -- Periodicals; 530.413
• DOI: 10.1080/00222348.2021.1876975
• Languages: English
• ISSNs: 0022-2348

Abstract

Abstract: Among drug delivery systems, polymer microspheres have been proved to be the most promising carriers during the past several years. In this paper we describe the preparation of poly(L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) random terpolymer microspheres; their in-vitro degradation behaviors, including the changes of pH value, mass loss, molecular mass and surface morphology, were investigated during various degradation periods and compared with poly(lactic-co-glycolic acid) (PLGA) microspheres. The results showed that the introduction of the ε-caprolactone (ε-CL) unit reduced the degradation rate of the PLGA polymers. Therefore, we suggest the PLLGC microspheres with controllable degradation rate could supply a wider application future in drug delivery field than pure PLGA microspheres.