Formaldehyde regulates tetrahydrofolate stability and thymidylate synthase catalysis. Issue 47 (17th May 2021)
- Record Type:
- Journal Article
- Title:
- Formaldehyde regulates tetrahydrofolate stability and thymidylate synthase catalysis. Issue 47 (17th May 2021)
- Main Title:
- Formaldehyde regulates tetrahydrofolate stability and thymidylate synthase catalysis
- Authors:
- Chen, Xiaolei
Chothia, Sara Y.
Basran, Jaswir
Hopkinson, Richard J. - Abstract:
- Abstract : NMR studies on the formation and stability of 5, 10-methylenetetrahydrofolic acid reveal a non-enzymatic feedback mechanism mediated by formaldehyde. Abstract : Tetrahydrofolic acid and formaldehyde are key human metabolites but their physiologically relevant chemistry is undefined. Our NMR studies confirm formaldehyde as a product of tetrahydrofolic acid degradation but also reveal their reaction regulates the stability of tetrahydrofolic acid. These observations identify a novel non-enzymatic feedback mechanism regulating formaldehyde and folate metabolism that has important implications for folate-targeting chemotherapy in cancer and other diseases.
- Is Part Of:
- Chemical communications. Volume 57:Issue 47(2021)
- Journal:
- Chemical communications
- Issue:
- Volume 57:Issue 47(2021)
- Issue Display:
- Volume 57, Issue 47 (2021)
- Year:
- 2021
- Volume:
- 57
- Issue:
- 47
- Issue Sort Value:
- 2021-0057-0047-0000
- Page Start:
- 5778
- Page End:
- 5781
- Publication Date:
- 2021-05-17
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1cc01425k ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 17239.xml