Front Cover: Antibacterial and Anti‐biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus (ChemBioChem 12/2021). (14th June 2021)

• Record Type: Journal Article
• Authors: Lu, Jacky; Francis, Jamisha D.; Guevara, Miriam A.; Moore, Rebecca E.; Chambers, Schuyler A.; Doster, Ryan S.; Eastman, Alison J.; Rogers, Lisa M.; Noble, Kristen N.; Manning, Shannon D.; Damo, Steven M.; Aronoff, David M.; Townsend, Steven D.; Gaddy, Jennifer A.
• Is Part Of: Chembiochem. Volume 22:Number 12(2021)
• Page Start: 2010
• Page End: 2010
• Publication Date: 2021-06-14
• Subjects: antimicrobial -- biofilms -- innate immunity -- lactoferrin -- Streptococcus; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.202100214
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The cover feature picture is a composite of a high‐resolution scanning electron microscopy (SEM) of Streptococcus agalactiae biofilms at high (10 000×) magnification pseudocolored purple with ribbon diagram structures of the lactoferrin molecule between cells. S. agalactiae, also known as Group B Streptococcus (GBS) is a bacterial pathogen that causes invasive infections during pregnancy that can lead to preterm birth and neonatal sepsis. The work demonstrates that the glycoprotein lactoferrin, which is a dominant component of human breast milk, can inhibit GBS growth, viability, biofilm formation, and adherence to reproductive tissues, such as gestational membranes. More information can be found in the Full Paper by S. D. Townsend, J. A. Gaddy et al.