Long‐term Outcomes of Juvenile Onset Recurrent Respiratory Papillomatosis with Pulmonary Involvement. (7th January 2021)

• Record Type: Journal Article
• Authors: Yang, Qingwen; Li, Yanru; Ma, Lijing; Xiao, Yang; Wang, Huijun; Ding, Yiming; Hu, Rong; Wang, Xiaoyi; Meng, Lingzhen; Wang, Jun; Xu, Wen
• Is Part Of: Laryngoscope. Volume 131:Number 7(2021)
• Page Start: EE2277
• Page End: E2283
• Publication Date: 2021-01-07
• Subjects: Papilloma of the respiratory tract -- prognosis -- tracheotomy -- lung; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.29376
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Objective: To investigate the clinical characteristics and long‐term outcomes of juvenile onset recurrent respiratory papillomatosis (JORRP) with or without pulmonary involvement. Methods: A group of patients with JORRP who had clinical course over an extended period of time (at least 5 years) in the Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital were included in this retrospective study. Lung/bronchus involvement was revealed by lung imaging. Data on mortality rate, frequency of surgical interventions, and age of disease onset were collected and analyzed. Results: The 192 patients (107 male and 85 female) included had a median [quartiles] age of JORRP onset of 2 [1, 4] years, and median follow‐up duration of 10 [7, 13] years; 17 patients (8.9%) had papilloma with bronchial and pulmonary involvement 7.0 [4.0, 12.5] years after the onset of the disease. Compared to patients without lung involvement, patients with lung involvement had a younger age of disease onset ( P = .001), higher frequency of surgical interventions ( P < .001), higher mortality rate (OR = 94.909), and an increased risk of tracheotomy that could not be decannulated ( P < .001). They also had a younger age of disease onset, and a higher frequency of surgical interventions and mortality compared to patients with tracheotomy but free from lung involvement ( P < .001). Conclusions: Children with JORRP and with pulmonary involvement have a higher average number of operations per year than those without pulmonary involvement, and pulmonary involvement indicates a higher incidence of tracheotomy that cannot be decannulated. Level of Evidence: 4 Laryngoscope, 131:E2277–E2283, 2021