2-Phenylindole derivatives as anticancer agents: synthesis and screening against murine melanoma, human lung and breast cancer cell lines. Issue 17 (2nd September 2019)

• Record Type: Journal Article
• Authors: Gaikwad, Ruchi; Bobde, Yamini; Ganesh, Routholla; Patel, Tarun; Rathore, Anju; Ghosh, Balaram; Das, Kalpataru; Gayen, Shovanlal
• Is Part Of: Synthetic communications. Volume 49:Issue 17(2019)
• Page Start: 2258
• Page End: 2269
• Publication Date: 2019-09-02
• Subjects: A549 -- B16F10 -- anticancer activity -- Fischer indole synthesis -- MDA-MB-231 -- molecular docking -- 2-phenylindole; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2019.1620282
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: Indole derivatives have attractive anticancer properties and may be a future hope for better anticancer drug(s) of low toxicity and high potency. In this paper, syntheses of 2-phenylindole derivatives have been described via Fischer indole synthesis through a one-pot solvent-free method. The synthesized compounds were screened for anticancer potential in vitro against murine melanoma (B16F10), human lung cancer (A549), and human breast cancer (MDA-MB-231) cell lines. The results highlighted that 2-phenylindole derivatives are also promising anticancer agents in case of melanoma and lung cancer along with the breast cancer. Molecular docking analyses with possible targets for melanoma (NEDD4-1) and lung cancer (EGFR) were also performed to understand specific interactions of 2-phenylindole derivatives with the amino acid residues of the receptors. GRAPHICAL ABSTRACT: UF0001