Bis(sulfanediyl)bis(6-aminopyrimidin-4-ones): Versatile precursors for novel bis(sulfanediyl)bis(tetrahydropyrimido[4, 5-b]quinoline-4, 6-diones) linked to aliphatic spacer via multi-component reactions. Issue 13 (3rd July 2021)

• Record Type: Journal Article
• Authors: Diab, Hadeer M.; Salem, Mostafa E.; Elwahy, Ahmed H. M.; Abdelhamid, Ismail A.
• Is Part Of: Synthetic communications. Volume 51:Issue 13(2021)
• Page Start: 2001
• Page End: 2015
• Publication Date: 2021-07-03
• Subjects: Aliphatic spacer -- bis(6-aminopyrimidin-4-ones) -- bis(sulfanediyl) -- bis(tetrahydropyrimido[4, 5-b]quinoline-4, 6-diones) -- multi-component reactions; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2021.1918172
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A synthesis of novel bis (sulfanediyl) bis (tetrahydropyrimido[4, 5- b ]quinoline-4, 6-diones), linked to aryl, heteroaryl, and spirocyclic-oxindole moieties at position-5, as novel hybrid molecules was reported. 2, 2'-(Butane-1, 4-diyl bis (sulfanediyl)) bis (6-aminopyrimidin-4(1 H )-one) was utilized as a precursor to our target compounds via a multicomponent reaction with two equivalents of both of the appropriate aldehyde and dimedone. The target compounds were alternatively obtained by bis -(alkylation) of the appropriate 5-aryl-2-thioxohexahydropyrimido[4, 5- b ]quinoline-4, 6-dione with 1, 4-dibromobutane in moderate basic medium. Graphical Abstract: UF0001