N-Heterocyclic carbene palladium (II)-pyridine (NHC-Pd (II)-Py) complex catalyzed heck reactions. Issue 13 (3rd July 2021)

• Record Type: Journal Article
• Authors: Li, Dan; Tian, Qingqiang; Wang, Xuetong; Wang, Qiang; Wang, Yin; Liao, Siwei; Xu, Ping; Huang, Xin; Yuan, Jianyong
• Is Part Of: Synthetic communications. Volume 51:Issue 13(2021)
• Page Start: 2041
• Page End: 2052
• Publication Date: 2021-07-03
• Subjects: NHC-Pd (II)-Py -- aromatic bromides -- olefins -- stilbene -- synthesis; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2021.1919711
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A mild, efficient, and practical catalytic system for the synthesis of highly privileged stilbene pharmacophores is reported. This system uses N-heterocyclic carbene palladium (II) Pyridine (NHC-Pd (II)-Py) complex to catalyze the formation of carbon-carbon bonds between olefin derivatives and various bromide. This simple, gentle and user-friendly method can offer a variety of stilbene products in excellent yields under solvent-free condition. And its scale-up reaction has excellent yield and this system can be applied to industrial fields. The utility of this method is highlighted by its universality and modular synthesis of a series of bioactive molecules or important medical intermediates. Graphical Abstract: UF0001