A novel peptide targeting c-Met for hepatocellular carcinoma diagnosis. Issue 22 (28th May 2021)

• Record Type: Journal Article
• Authors: Tang, Yongjia; Xu, Haoran; Dai, Yaxue; Wang, Fang; Huang, Wenjing; Liu, Peifei; Gu, Yueqing
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 22(2021)
• Page Start: 4577
• Page End: 4586
• Publication Date: 2021-05-28
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb00408e
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Fluorescence and SPECT imaging of tumors with different c-Met expression. Abstract : Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with limited diagnosis. Mesenchymal epithelial transition factor (c-Met) has become a hot target for cancer diagnosis and therapy, which is overexpressed in HCC. In this study, we labeled a novel c-Met targeting peptide YQ-M3 with a near-infrared fluorescent dye MPA and a radionuclide technetium-99m for HCC detection. YQ-M3-MPA showed high affinity for c-Met positive HepG2 tumor in vitro and higher tumor uptake and higher T/N ratio than GE137-MPA (a positive tracer for c-Met) in HepG2 tumor-bearing mice in vivo by fluorescence imaging. In addition, 99m Tc-HYNIC-YQ-M3 also showed significant tumor uptake in vivo through SPECT imaging. These results indicated that c-Met positive tumors were successfully detected via fluorescence and SPECT imaging using YQ-M3-MPA and 99m Tc-HYNIC-YQ-M3, respectively, and further suggested that YQ-M3-MPA and 99m Tc-HYNIC-YQ-M3 have some possibly potential clinical applications for HCC diagnosis.