Alternative mechanism of action of the DNP PtIV prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway. Issue 23 (25th May 2021)

• Record Type: Journal Article
• Authors: Krasnovskaya, Olga; Spector, Daniil; Erofeev, Alexander; Gorelkin, Peter; Akasov, Roman; Skvortsov, Dmitry; Trigub, Alexander; Vlasova, Ksenia; Semkina, Alevtina; Zyk, Nikolay; Beloglazkina, Elena; Majouga, Alexander
• Is Part Of: Dalton transactions. Volume 50:Issue 23(2021)
• Page Start: 7922
• Page End: 7927
• Publication Date: 2021-05-25
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d1dt00898f
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A mechanism of action of the previously reported Pt(iv ) prodrug with non-steroidal anti-inflammatory drug naproxen in axial positions (DNP), it's therapeutic target and intracellular redox-status are clarified. Abstract : In a recent research paper Dr. Suxing Jin et al. reported two multispecific Pt IV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.