Access to the C2 C–H olefination, alkylation and deuteration of indoles by rhodium(iii) catalysis: an opportunity for diverse syntheses. Issue 12 (16th April 2021)

• Record Type: Journal Article
• Authors: Wu, Jiaping; Qian, Baiyang; Lu, Lili; Yang, Haitao; Shang, Yongjia; Zhang, Jitan
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 12(2021)
• Page Start: 3032
• Page End: 3040
• Publication Date: 2021-04-16
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo00133g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A concise approach for a diversity-oriented synthesis via regioselective C2 C–H olefination, alkylation, and deuteration of indoles by Rh(iii ) catalysis is described. Abstract : A concise approach for the synthesis of structurally diverse indoles enabled by Rh III -catalyzed switchable C2 C–H olefination and alkylation of N -quinolinyl indoles with alkenes as well as highly efficient C–H deuteration is described. The reaction can be conducted under practical reaction conditions, with a broad substrate scope and good tolerance of various functional groups. The potential value of this synthetic methodology is shown by the diverse late-stage modification of the products, thereby providing a straightforward route to access functionalized indoles, especially indole-based P, N ligands.