Nongenetic control of receptor signaling dynamics using a DNA-based optochemical tool. Issue 48 (24th May 2021)

• Record Type: Journal Article
• Authors: Ueki, Ryosuke; Hayashi, Shota; Tsunoda, Masaya; Akiyama, Momoko; Liu, Hanrui; Ueno, Tasuku; Urano, Yasuteru; Sando, Shinsuke
• Is Part Of: Chemical communications. Volume 57:Issue 48(2021)
• Page Start: 5969
• Page End: 5972
• Publication Date: 2021-05-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc01968f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We demonstrated the nongenetic temporal control of cell signaling using a DNA-based synthetic surrogate of growth factor. Abstract : Optochemical tools that can modulate the activity of the target protein provide an opportunity for studying and regulating the related biological processes. Here we present a DNA-based nongenetic optochemical tool that can control the dynamics of growth factor signaling. This photo-caged mimicry of growth factor can be a promising tool for elucidating a linkage between the dynamics of signaling and the resulting biological outcomes, as well as for manipulating cellular functions and the fate of living cells.