N-Heterocyclic carbene-catalyzed [3 + 3] annulation of bromoenals with 2-aminochromones to access chromeno[2, 3-b]pyridinones. Issue 22 (20th May 2021)

• Record Type: Journal Article
• Authors: Jiang, Pengrui; Guo, Jingcheng; Gong, Minghua; Zhou, Xiangui; Cao, Wei; Fu, Zhenqian; Huang, Wei
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 22(2021)
• Page Start: 4882
• Page End: 4886
• Publication Date: 2021-05-20
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00720c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : 2-Aminochromones were found as novel enamines used in N-heterocyclic carbene-catalyzed [3 + 3] annulation, delivering a structurally diverse set of chromeno[2, 3- b ]pyridinones. Abstract : N-Heterocyclic carbene-catalyzed [3 + 3] annulation of bromoenals with 2-aminochromones has been successfully developed. A structurally diverse set of chromeno[2, 3- b ]pyridinones was efficiently constructed in acceptable to excellent yields. The reaction features mild reaction conditions, a broad substrate scope, and easy scale-up.