V for versatility: TRPV4 Ca2+ entry channel plays multiple roles in invadosome regulation. (June 2021)

• Record Type: Journal Article
• Authors: Mori, Yasuo
• Is Part Of: Cell calcium. Volume 96(2021)
• Publication Date: 2021-06
• Subjects: Cell invasion -- Invadosome -- Acto-adhesive structure -- ECM -- β1-Integrins -- TRPV4 -- ROS -- ASK1 -- PI(4, 5)P2; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2021.102387
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: Several Ca 2+ -permeable cation channels attract attention for their mechanotransducer function to evoke Ca 2+ signals in cell invasion. Vellino et al., have clarified the versatility of the osmo-sensing TRPV4 channel in regulating invadosome functions: TRPV4 detects and integrates multiple cellular and environmental cues, triggering Ca 2+ signals and molecular interactions that modulate coupling between acto-adhesion and extracellular matrix degradation.