TRPM4 keeps up the pace. (June 2021)

• Record Type: Journal Article
• Authors: Ambroziak, Wojciech; Siemens, Jan
• Is Part Of: Cell calcium. Volume 96(2021)
• Publication Date: 2021-06
• Subjects: Trp ion channel -- pacemaking -- action potential -- autonomous firing; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2021.102401
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: The study by Li et al., provides a detailed pharmacological characterization of the ionic mechanisms that underlie rhythmic activity of retrotrapezoid nucleus neurons that control breathing. Specifically, the authors demonstrate a role of the transient receptor potential melastatin 4 (TRPM4) ion channel in the generation of subthreshold excitatory oscillations. Additionally, they propose that the ion channel contributes to tonic action potential (AP) firing – referred to as "pacemaking" – of these brainstem neurons with relevance for respiratory breathing and homeostasis in vivo .