Sodium ion channels as potential therapeutic targets for cancer metastasis. Issue 5 (May 2021)

• Record Type: Journal Article
• Authors: Horne, Jesse; Mansur, Shomit; Bao, Yuping
• Is Part Of: Drug discovery today. Volume 26:Issue 5(2021)
• Page Start: 1136
• Page End: 1147
• Publication Date: 2021-05
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2021.01.026
• Languages: English
• ISSNs: 1359-6446

Abstract

Graphical abstract: Highlights: Voltage-gated sodium channel subtypes identified in metastatic cancers. Locations available offering subtype specificity among sodium channels. Specific sites for the development of drugs targeting metastatic cancers. Sodium channels as promising therapeutic targets for cancer metastasis. Many studies have shown the involvement of voltage-gated sodium channels (VGSCs) in cancer metastasis. However, a comprehensive review of using VGSCs as therapeutic targets for metastatic cancer drug development is still lacking. Here, we discuss the structural differences across VGSC subtypes and in the isoforms involving metastatic cancers. These structural variations are the basis for designing drug molecules with potential subtype selectivity. We also summarize the expression and activities of different VGSCs in certain types of cancer and possible mechanisms of action. Finally, we elaborate on the molecule-binding sites of VGSCs, emphasizing locations with potential in metastatic cancer drug development. Teaser: Is it possible to develop drugs for the treatment of a specific type of metastatic cancer by targeting sodium ion channels?