Cyclodextrin polymers: Structure, synthesis, and use as drug carriers. (July 2021)

• Record Type: Journal Article
• Authors: Liu, Zongjian; Ye, Lin; Xi, Jianing; Wang, Jin; Feng, Zeng-guo
• Is Part Of: Progress in polymer science. Volume 118(2021)
• Publication Date: 2021-07
• Subjects: Cyclodextrin -- Polyrotaxane -- Grafted CDs -- Star polymer -- Drug delivery; ATRP atom transfer radical polymerization -- ATS artesunate -- BBB blood-brain barrier -- BM Benzimidazole -- CAR carvedilol -- CD cyclodextrin -- CDPs cyclodextrin-based polymers -- C-CDPs cross-linked cyclodextrin polymers -- CD-PR cyclodextrin-based polyrotaxane -- CLN cross-linking networks -- CNT carbon nano tubes -- DFO deferoxamine -- DOX doxorubicin -- ECH 1-chloro-2, 3-epoxypropane -- EPI epichlorohydrin -- EPR enhanced permeability and retention -- G-CDP grafted cyclodextrin polymer -- GSH glutathione -- HP-β-CD hydroxypropyl-β-cyclodextrin -- HCPT 10-hydroxycamptothecin -- HA hyaluronic acid -- IC inclusion complexe -- MOF metal-organic framework -- MSP mesoporous silica particle -- NS nanosponge -- PAM Polyacrylamide -- PBMA poly(n-butyl methacrylate) -- PDETA poly(diethylenetriamine) -- PDMA poly(2-(dimethylamino)ethyl methacrylate) -- PEDA Poly(ethylenediamine) -- PEI poly(ethylenimine) -- PEO poly(ethylene oxide) -- PEGMA poly(ethylene glycol) methyl ether methacrylate -- PGAMA poly(d-gluconamidoethyl methacrylate) -- PGMA poly(glycidyl methacrylate) -- PHEAm poly(N-(2-hydroxyethyl)acrylamide) -- PHEMA poly(2-hydroxyethylmethacrylate) -- PHPMA poly(2-hydroxypropyl methacrylate) -- PHEMA-b-PCB-tBu poly(2-hydroxyethyl methacrylate)-block-poly(2-ter-butoxy-N-(2-(methacryloyloxy)ethyl)-N, N-dimethyl-2-oxoethanaminuim) -- PMA poly(propargyl methacrylate) -- PMAA poly(methacrylic acid) -- PMGMA-b-POEGMA poly(ethyl glycinate methacrylamide)-block-poly(ethylene glycol)methyl ether methacrylate -- PMMA poly(methyl methacrylate) -- PNIPAAm poly(N-isopropylacrylamide) -- PLA poly(lactic acid) -- PR polyrotaxane -- PPR poly(pseudo)rotaxane -- PpIX protoporphyrin -- PPY polypyrrole -- ROP ring-opening polymerization -- TPGS D-α-tocopheryl PEG-1000 succinate -- SCU scutellarin -- star-CDP cyclodextrin-based star polymer -- SSA specific surface area; Polymers -- Periodicals; Polymerization -- Periodicals; Polymers -- Industrial applications -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.progpolymsci.2021.101408
• Languages: English
• ISSNs: 0079-6700

Abstract

Abstract: Cyclodextrin-based polymers (CDPs) are amphiphilic macromolecules owing to their unique structure and the presence of multiple hydroxyl groups. These polymers have become increasingly popular in applications ranging from biomedicine to environmental science. In this review, four types of CDPs are distinguished based on their structural characteristics: cyclodextrin-based polyrotaxanes, grafted cyclodextrin polymers, cross-linked cyclodextrin polymers, and cyclodextrin-originated star/multi-arm polymers. The discussion includes the syntheses and properties of several derivatives of CDPs. In addition to low toxicity, good bioavailability and biodegradability, and the feasibility of inclusion complexation and chemical modification of cyclodextrins, these polymers have prominent advantages, such as stimuli responsiveness and the ability to form well-defined aggregated nanostructures, which make them promising candidates for applications related to controlled and targeted drug delivery. In this review, we have highlighted the evolution, unique types, and properties of various CDPs, which are core aspects that differ from previously published reviews. Additionally, the synergistic effect of cyclodextrin and cross-linking monomers, as well as their use as drug carriers over the past decade, have been emphasized. Graphical abstract: Image, graphical abstract