TRPA1 channel: New kid in the 'neurovascular coupling' town. (June 2021)

• Record Type: Journal Article
• Authors: Sancho, Maria; Nelson, Mark T.
• Is Part Of: Cell calcium. Volume 96(2021)
• Publication Date: 2021-06
• Subjects: Neurovascular coupling -- Functional hyperemia -- TRPA1 channels -- Calcium signaling -- Capillary endothelium -- Cerebral blood flow; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2021.102407
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: The just-in time delivery of oxygen and nutrients to active brain regions to support function (functional hyperemia; FH) is mediated by not yet fully understood mechanisms collectively referred to as 'neurovascular coupling' (NVC). In a recent publication (eLife 2021) Thakore et al. provide profound mechanistic insight how the capillary endothelial transient receptor potential ankyrin 1 (TRPA1) channel contribute to blood flow control and functional hyperemia in the brain.