Controlled release of iodine from cross-linked cyclodextrin metal-organic frameworks for prolonged periodontal pocket therapy. (1st September 2021)

• Record Type: Journal Article
• Authors: Lu, Shan; Ren, Xiaohong; Guo, Tao; Cao, Zeying; Sun, Hongyu; Wang, Caifen; Wang, Fangyuan; Shu, Zixuan; Hao, Jinghua; Gui, Shuangying; Lei, Chuanhu; Zhang, Jiwen
• Is Part Of: Carbohydrate polymers. Volume 267(2021)
• Publication Date: 2021-09-01
• Subjects: Iodine -- Cross-linked cyclodextrin metal-organic frameworks -- Controlled release -- Periodontitis -- Minocycline; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118187
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Effective therapeutic system to periodontitis was designed using cross-linked cyclodextrin metal-organic framework (COF) as carrier for iodine and further suspended in hydroxyethyl cellulose gel as I2 @COF-HEC hydrogel. Inclusion of iodine within the COF was demonstrated by SR-FTIR spectral and characteristic DSC and TGA changes. Molecular modelling identified the interaction of iodine with both COF central cavity and individual cyclodextrin moieties of COF. In vitro results of study demonstrated that iodine release in artificial saliva from I2 @COF-HEC hydrogel could be extended up to 5 days, which was slower than I2 @COF particles. Using an in vivo rat model of periodontitis, micro-computed tomography of alveolar bone morphology demonstrated that I2 @COF-HEC hydrogel showed similar effects in decreasing periodontal pocket depth and alveolar bone resorption to minocycline ointment, a periodontitis antibiotic. The I2 @COF-HEC hydrogel is a novel local delivery device of iodine as a broad spectrum antimicrobial use for treatment of periodontitis. Graphical abstract: Unlabelled Image Highlights: Iodine loaded COF particles were synthesized and made into I2 @COF-HEC hydrogel to elongate the release of iodine up to 5 d. The characterizations demonstrated that the mechanism of iodine loading in COF was the formation of clathrate compound. The I2 @COF-HEC hydrogel exhibited therapeutic effects comparable to minocycline hydrochloride ointment.