Vitamin D and breast cancer: evidence for biological and clinical significance. (July 2012)

• Record Type: Journal Article
• Authors: Clark, Amy S; DeMichele, Angela
• Is Part Of: Breast cancer management. Volume 1:Number 2(2012)
• Page Start: 143
• Page End: 155
• Publication Date: 2012-07
• Subjects: Breast -- Cancer -- Periodicals; Breast -- Cancer -- Treatment -- Periodicals; 616.9944905
• DOI: 10.2217/bmt.12.28
• Languages: English
• ISSNs: 1758-1923

Abstract

SUMMARY Both vitamin D deficiency and breast cancer are common. Laboratory evidence strongly suggests a biological role for vitamin D in normal breast cellular maintenance. Clinically, however, definitive associations between vitamin D and breast cancer risk and outcome have been challenging to decipher. A myriad of epidemiological studies have attempted to connect vitamin D with breast cancer risk, stage at diagnosis and outcome, but results vary. Here, we will closely examine the biologic evidence that supports an association between vitamin D and breast cancer and summarize the epidemiologic and clinical studies in this area. We will discuss ongoing trials and additional research questions that should be addressed in future studies.