Respiratory exacerbations are associated with muscle loss in current and former smokers. Issue 6 (11th February 2021)

• Record Type: Journal Article
• Authors: Mason, Stefanie Elizabeth; Moreta-Martinez, Rafael; Labaki, Wassim W; Strand, Matthew; Baraghoshi, David; Regan, Elizabeth A; Bon, Jessica; San Jose Estepar, Ruben; Casaburi, Richard; McDonald, Merry-Lynn N; Rossiter, Harry; Make, Barry J; Dransfield, Mark T; Han, MeiLan K; Young, Kendra A; Kinney, Greg; Hokanson, John E; San Jose Estepar, Raul; Washko, George R
• Other Names: author non-byline.; Crapo James D. author non-byline.; Silverman Edwin K. author non-byline.; Make Barry J. author non-byline.; Regan Elizabeth A. author non-byline.; Beaty Terri author non-byline.; Begum Ferdouse author non-byline.; Castaldi Peter J. author non-byline.; Cho Michael author non-byline.; DeMeo Dawn L. author non-byline.; Boueiz Adel R. author non-byline.; Foreman Marilyn G. author non-byline.; Halper-Stromberg Eitan author non-byline.; Hayden Lystra P. author non-byline.; Hersh Craig P. author non-byline.; Hetmanski Jacqueline author non-byline.; Hobbs Brian D. author non-byline.; Hokanson John E. author non-byline.; Laird Nan author non-byline.; Lange Christoph author non-byline.; Lutz Sharon M. author non-byline.; McDonald Merry-Lynn author non-byline.; Parker Margaret M. author non-byline.; Prokopenko Dmitry author non-byline.; Qiao Dandi author non-byline.; Regan Elizabeth A. author non-byline.; Sakornsakolpat Phuwanat author non-byline.; Silverman Edwin K. author non-byline.; Wan Emily S. author non-byline.; Won Sungho author non-byline.; Centeno Juan Pablo author non-byline.; Charbonnier Jean-Paul author non-byline.; Coxson Harvey O. author non-byline.; Galban Craig J. author non-byline.; Han MeiLan K. author non-byline.; Hoffman Eric A. author non-byline.; Humphries Stephen author non-byline.; Jacobson Francine L. author non-byline.; Judy Philip F. author non-byline.; Kazerooni Ella A. author non-byline.; Kluiber Alex author non-byline.; Lynch David A. author non-byline.; Nardelli Pietro author non-byline.; Newell John D. author non-byline.; Notary Aleena author non-byline.; Oh Andrea author non-byline.; Regan Elizabeth A. author non-byline.; Ross James C. author non-byline.; Estepar Raul San Jose author non-byline.; Schroeder Joyce author non-byline.; Sieren Jered author non-byline.; Stoel Berend C. author non-byline.; Tschirren Juerg author non-byline.; Beek Edwin Van author non-byline.; Ginneken Bram van author non-byline.; Rikxoort Eva van author non-byline.; Sanchez-Ferrero Gonzalo Vegas author non-byline.; Veitel Lucas author non-byline.; Washko George R. author non-byline.; Wilson Carla G. author non-byline.; Jensen Robert author non-byline.; Everett Douglas author non-byline.; Crooks Jim author non-byline.; Pratte Katherine author non-byline.; Strand Matt author non-byline.; Wilson Carla G. author non-byline.; Hokanson John E. author non-byline.; Kinney Gregory author non-byline.; Lutz Sharon M. author non-byline.; Young Kendra A. author non-byline.; Bhatt Surya P. author non-byline.; Bon Jessica author non-byline.; Diaz Alejandro A. author non-byline.; Han MeiLan K. author non-byline.; Make Barry author non-byline.; Murray Susan author non-byline.; Regan Elizabeth author non-byline.; Soler Xavier author non-byline.; Wilson Carla G. author non-byline.; Bowler Russell P. author non-byline.; Kechris Katerina author non-byline.; Banaei-Kashani Farnoush author non-byline.; Curtis Jeffrey L. author non-byline.; Pernicano Perry G. author non-byline.; Hanania Nicola author non-byline.; Atik Mustafa author non-byline.; Boriek Aladin author non-byline.; Guntupalli Kalpatha author non-byline.; Guy Elizabeth author non-byline.; Parulekar Amit author non-byline.; DeMeo Dawn L. author non-byline.; Diaz Alejandro A. author non-byline.; Hayden Lystra P. author non-byline.; Hobbs Brian D. author non-byline.; Hersh Craig author non-byline.; Jacobson Francine L. author non-byline.; Washko George author non-byline.; Graham Barr R. author non-byline.; Austin John author non-byline.; D'Souza Belinda author non-byline.; Thomashow Byron author non-byline.; MacIntyre Neil author non-byline.; Page McAdams H. author non-byline.; Washington Lacey author non-byline.; Flenaugh Eric author non-byline.; Terpenning Silanth author non-byline.; McEvoy Charlene author non-byline.; Tashjian Joseph author non-byline.; Wise Robert author non-byline.; Brown Robert author non-byline.; Hansel Nadia N. author non-byline.; Horton Karen author non-byline.; Lambert Allison author non-byline.; Putcha Nirupama author non-byline.; Casaburi Richard author non-byline.; Adami Alessandra author non-byline.; Budoff Matthew author non-byline.; Fischer Hans author non-byline.; Porszasz Janos author non-byline.; Rossiter Harry author non-byline.; DeBakey Michael E. author non-byline.; Sharafkhaneh Amir author non-byline.; Lan Charlie author non-byline.; Bowler Russell author non-byline.; Lynch David A. author non-byline.; Rosiello Richard author non-byline.; Pace David author non-byline.; Criner Gerard author non-byline.; Ciccolella David author non-byline.; Cordova Francis author non-byline.; Dass Chandra author non-byline.; D'Alonzo Gilbert author non-byline.; Desai Parag author non-byline.; Jacobs Michael author non-byline.; Kelsen Steven author non-byline.; Kim Victor author non-byline.; James Mamary A. author non-byline.; Marchetti Nathaniel author non-byline.; Satti Aditi author non-byline.; Shenoy Kartik author non-byline.; Steiner Robert M. author non-byline.; Swift Alex author non-byline.; Swift Irene author non-byline.; Vega-Sanchez Maria Elena author non-byline.; Dransfield Mark author non-byline.; Bailey William author non-byline.; Bhatt Surya P. author non-byline.; Iyer Anand author non-byline.; Nath Hrudaya author non-byline.; Michael Wells J. author non-byline.; Conrad Douglas author non-byline.; Soler Xavier author non-byline.; Yen Andrew author non-byline.; Comellas Alejandro P. author non-byline.; Hoth Karin F. author non-byline.; Newell John author non-byline.; Thompson Brad author non-byline.; Han MeiLan K. author non-byline.; Kazerooni Ella author non-byline.; Labaki Wassim author non-byline.; Galban Craig author non-byline.; Vummidi Dharshan author non-byline.; Billings Joanne author non-byline.; Begnaud Abbie author non-byline.; Allen Tadashi author non-byline.; Sciurba Frank author non-byline.; Bon Jessica author non-byline.; Chandra Divay author non-byline.; Weissfeld Joel author non-byline.; Anzueto Antonio author non-byline.; Adams Sandra author non-byline.; Maselli-Caceres Diego author non-byline.; Ruiz Mario E. author non-byline.; Singh Harjinder author non-byline.;
• Is Part Of: Thorax. Volume 76:Issue 6(2021)
• Page Start: 554
• Page End: 560
• Publication Date: 2021-02-11
• Subjects: COPD exacerbations -- imaging/CT MRI etc -- pulmonary rehabilitation; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2020-215999
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Objectives: Muscle wasting is a recognised extra-pulmonary complication in chronic obstructive pulmonary disease and has been associated with increased risk of death. Acute respiratory exacerbations are associated with reduction of muscle function, but there is a paucity of data on their long-term effect. This study explores the relationship between acute respiratory exacerbations and long-term muscle loss using serial measurements of CT derived pectoralis muscle area (PMA). Design and setting: Participants were included from two prospective, longitudinal, observational, multicentre cohorts of ever-smokers with at least 10 pack-year history. Participants: The primary analysis included 1332 (of 2501) participants from Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) and 4384 (of 10 198) participants from Genetic Epidemiology of COPD (COPDGene) who had complete data from their baseline and follow-up visits. Interventions: PMA was measured on chest CT scans at two timepoints. Self-reported exacerbation data were collected from participants in both studies through the use of periodic longitudinal surveys. Main outcome measures: Age-related and excess muscle loss over time. Results: Age, sex, race and body mass index were associated with baseline PMA. Participants experienced age-related decline at the upper end of reported normal ranges. In ECLIPSE, the exacerbation rate over time was associated with an excess muscle area loss of 1.3% (95% CI 0.6 to 1.9, p<0.001) over 3 years and in COPDGene with an excess muscle area loss of 2.1% (95% CI 1.2 to 2.8, p<0.001) over 5 years. Excess muscle area decline was absent in 273 individuals who participated in pulmonary rehabilitation. Conclusions: Exacerbations are associated with accelerated skeletal muscle loss. Each annual exacerbation was associated with the equivalent of 6 months of age-expected decline in muscle mass. Ameliorating exacerbation-associated muscle loss represents an important therapeutic target.