Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats. Issue 4 (15th March 2021)

• Record Type: Journal Article
• Authors: Ambalavanan, Ragavee; John, Arul Daniel; Selvaraj, Asha Devi
• Other Names: Nirmala Grace A. guestEditor.; Vimala R. guestEditor.; Sellappan Raja guestEditor.; Jacob George guestEditor.; Mangaiyarkarasi R guestEditor.
• Is Part Of: IET nanobiotechnology. Volume 15:Issue 4(2021)
• Page Start: 411
• Page End: 417
• Publication Date: 2021-03-15
• Subjects: Biotechnology -- Periodicals; Nanotechnology -- Periodicals; 660.6
• DOI: 10.1049/nbt2.12030
• Languages: English
• ISSNs: 1751-8741

Abstract

Abstract: Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC‐loaded PLA Nanoparticles (TC‐PLA NPs) on streptozotocin (STZ)‐induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC‐PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy.