Occurrence of hepatitis in an elderly woman during the treatment of pembrolizumab for right advanced renal pelvis, ureteral cancer, and bladder cancer. Issue 6 (6th May 2021)

• Record Type: Journal Article
• Authors: Asatani, Shinya; Kanda, Tatsuo; Honda, Masayuki; Ishii, Tomotaka; Yamana, Yoichiro; Kaneko, Tomohiro; Mizutani, Taku; Takahashi, Hiroshi; Kumagawa, Mariko; Sasaki, Reina; Masuzaki, Ryota; Kanezawa, Shini; Matsumoto, Naoki; Nirei, Kazushige; Yamagami, Hiroaki; Moriyama, Mitsuhiko
• Is Part Of: JGH open. Volume 5:Issue 6(2021)
• Page Start: 722
• Page End: 724
• Publication Date: 2021-05-06
• Subjects: hepatitis -- immune‐related adverse event -- pembrolizumab -- renal pelvis and ureteral cancer -- steroid
• DOI: 10.1002/jgh3.12554
• Languages: English
• ISSNs: 2397-9070

Abstract

Abstract: Recently, the use of immune checkpoint inhibitors (ICIs) with or without chemotherapeutic agents has been increasing in the treatment for advanced cancer. Here, we report the occurrence of liver failure after the use of pembrolizumab in an 82‐year‐old woman with metastatic liver disease derived from right advanced renal pelvis, ureteral cancer, and bladder cancer. She was successfully treated with 0.6 mg/kg daily prednisolone. In patients treated with ICIs, ICI‐induced hepatitis is occasionally observed. Even if patients are older, it appears important to diagnose and treat ICI‐induced hepatitis earlier by multidisciplinary therapies including steroid treatment. This is a first report of pembrolizumab‐induced liver failure in elder patient with age over 80 years. Even if patients are older, it appears important to diagnose and treat ICI‐induced hepatitis earlier by multidisciplinary therapies including steroid treatment. Abstract : We experienced the occurrence of liver failure after the use of pembrolizumab in an 82‐year‐old woman with metastatic liver disease. Immune checkpoint inhibitor‐induced hepatitis is occasionally observed. It seems important to diagnose and treat older patients with immune checkpoint inhibitor‐induced hepatitis earlier by multidisciplinary therapies.