Belatacept‐based immunosuppression: A calcineurin inhibitor‐sparing regimen in heart transplant recipients. Issue 2 (26th September 2019)

• Record Type: Journal Article
• Authors: Launay, Manon; Guitard, Joelle; Dorent, Richard; Prevot, Yoann; Prion, Florent; Beaumont, Laurence; Kably, Benjamin; Lecuyer, Lucien; Billaud, Eliane M.; Guillemain, Romain
• Is Part Of: American journal of transplantation. Volume 20:Issue 2(2020)
• Page Start: 553
• Page End: 563
• Publication Date: 2019-09-26
• Subjects: clinical research/practice -- heart transplantation/cardiology -- immunosuppressant ‐ fusion proteins and monoclonal antibodies: belatacept -- kidney failure / injury; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.15584
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Belatacept (BTC) is indicated for prophylaxis of graft rejection in adults receiving a renal transplant (Tx). This retrospective observational study (three centers) included all heart transplant recipients receiving BTC between January 2014 and October 2018. Forty EBV+ patients mean GFR 35 ± 20 mL/min/m 2 were identified, among whom belatacept was initiated during the first 3 months after transplantation in 12 patients, and later in 28 patients. Several patients were multiorgan transplant recipients. Study outcomes were GFR, safety, and changes in immunosuppressive therapy. The main reason for switching to BTC was to preserve renal function, resulting in discontinuation of CNI and changes in immunosuppressive therapy in 76% of cases. At study closeout, 24/40 patients were still on BTC therapy. GFR was improved (+59%, P = .0002*) within 1 month, particularly in the early group. More episodes of rejection were observed among "late" patients (1 death). Sixteen treatment discontinuations were recorded: GFR recovery (n = 4), DSA no longer detectable (n = 1), compliance issues (n = 3), poor venous access (n = 2), multiple infections (n = 1), 1 death (fungal lung infection), and treatment failure (n = 4). Median follow‐up was 24 months. Four patients developed de novo DSA (MFI<1500). BTC is an effective alternative immunosuppressive for postoperative transient kidney failure, stabilizing delayed renal function, with acceptable safety profile under careful monitoring. Abstract : Belatacept is used in 40 heart transplant recipients as alternative immunosuppressive therapy, especially in postoperative transient kidney failure or to stabilize prolonged impaired renal function, with a favorable safety profile.