NIR‐II J‐Aggregates Labelled Mesoporous Implant for Imaging‐Guided Osteosynthesis with Minimal Invasion. (31st March 2021)

• Record Type: Journal Article
• Authors: Sun, Caixia; Sun, Xiaofei; Pei, Peng; He, Haisheng; Ming, Jiang; Liu, Xuan; Liu, Minchao; Zhang, Yuntong; Xia, Yan; Zhao, Dongyuan; Li, Xiaomin; Xie, Yang; Zhang, Fan
• Is Part Of: Advanced functional materials. Volume 31:Number 23(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-31
• Subjects: FD‐1080 J‐aggregates -- mesoporous silica layers -- mesoporous structures -- NIR‐II fluorescence imaging; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202100656
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Medical implants are widely used in clinical practice, such as cardiovascular stenting, maxillofacial surgery, and orthopedics. However, most of the traditional implant operations are open and invasive, resulting in massive dissection of soft tissue and interruption of blood supply. The accurate navigation for the implant operations is considered as one of the most effective ways to reduce the damage, which is urgently desired in clinic. Herein, a biocompatible NIR‐II J‐aggregates labelled mesoporous implant for imaging‐guided osteosynthesis with minimal invasion is reported. Mesoporous silica layer with vertical channels is grown on the surface of titanium plate, which can provide the confining space for the formation of the FD‐1080 J‐aggregates. Both the absorption and fluorescence peaks of the FD‐1080 J‐aggregates are located in NIR‐II window (beyond 1300 nm), which are ideal for high resolution and real time surgical navigation in deep tissue. NIR‐II imaging can clearly display the location and outline of the implant both in vitro and in vivo. This NIR‐II imaging‐guided osteosynthesis can effectively reduce the surgical wound and operational duration, which is crucial for the implant surgeries. Abstract : A biocompatible NIR‐II J‐aggregates labelled silica layer coated titanium plates (MSTPs‐FDJ@PAA) are developed for imaging‐guided osteosynthesis with minimal surgical wound and operational duration. This work not only provides a unique route for the preparation of medical implant with unique NIR‐II optical properties, but also establishes a potential platform for the precise navigation of the implantable medical devices.