Plaque morphology in acute symptomatic intracranial atherosclerotic disease. Issue 4 (25th November 2020)

• Record Type: Journal Article
• Authors: Leung, Thomas W; Wang, Li; Zou, Xinying; Soo, Yannie; Pu, Yuehua; Ip, Hing Lung; Chan, Anne; Au, Lisa Wing Chi; Fan, Florence; Ma, Sze Ho; Ip, Bonaventure; Ma, Karen; Lau, Alexander Yuk-lun; Leung, Howan; Hui, Kwok Fai; Li, Richard; Li, Siu Hung; Fu, Michael; Fong, Wing Chi; Liu, Jia; Mok, Vincent; Wong, Ka Sing Lawrence; Miao, Zhongrong; Ma, Ning; Yu, Simon C H; Leng, Xinyi
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 92:Issue 4(2021)
• Page Start: 370
• Page End: 376
• Publication Date: 2020-11-25
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2020-325027
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Background: Intracranial atherosclerotic disease (ICAD) is globally a major ischaemic stroke subtype with high recurrence. Understanding the morphology of symptomatic ICAD plaques, largely unknown by far, may help identify vulnerable lesions prone to relapse. Methods: We prospectively recruited patients with acute ischaemic stroke or transient ischaemic attack attributed to high-grade ICAD (60%–99% stenosis). Plaque morphological parameters were assessed in three-dimensional rotational angiography, including surface contour, luminal stenosis, plaque length/thickness, upstream shoulder angulation, axial/longitudinal plaque distribution and presence of adjoining branch atheromatous disease (BAD). We compared morphological features of smooth, irregular and ulcerative plaques and correlated them with cerebral ischaemic lesion load downstream in MRI. Results: Among 180 recruited patients (median age=60 years; 63.3% male; median stenosis=75%), plaque contour was smooth (51 (28.3%)), irregular (101 (56.1%)) or ulcerative (28 (15.6%)). Surface ulcers were mostly at proximal (46.4%) and middle one-third (35.7%) of the lesions. Most (84.4%) plaques were eccentric, and half had their maximum thickness over the distal end. Ulcerative lesions were thicker (medians 1.6 vs 1.3 mm; p=0.003), had steeper upstream shoulder angulation (56.2° vs 31.0° ; p<0.001) and more adjoining BAD (83.3% vs 57.0%; p=0.033) than non-ulcerative plaques. Ulcerative plaques were significantly associated with coexisting acute and chronic infarcts downstream (35.7% vs 12.5%; adjusted OR 4.29, 95% CI 1.65 to 11.14, p=0.003). Sensitivity analyses in patients with anterior-circulation ICAD lesions showed similar results in the associations between the plaque types and infarct load. Conclusions: Ulcerative intracranial atherosclerotic plaques were associated with vulnerable morphological features and had a higher cumulative infarct load downstream.