Adoptive T-cell Therapy with CD45RA-depleted Donor in the Treatment of Cytomegalovirus Disease in Immunocompromised Non-transplant Patients. Issue 4 (May 2019)

• Record Type: Journal Article
• Authors: Yuste, Jose R; de Cerio, Ascensión López-Díaz; Rifón, Jose; Moreno, Cristina; Panizo, María; Inogés, Susana
• Is Part Of: Antiviral therapy. Volume 24:Issue 4(2019)
• Page Start: 313
• Page End: 319
• Publication Date: 2019-05
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP3307
• Languages: English
• ISSNs: 1359-6535

Abstract

Cytomegalovirus (CMV) infections can induce severe complications in immunosuppressed patients. Currently, ganciclovir represents the preferred treatment option; however, in patients with resistance or toxicity related to ganciclovir, the therapeutic options are limited. Cellular immunity plays an important role in the control of viral infections. Adoptive T-cell therapy can contribute to recovering immunological function in immunosuppressed patients. Selective T-cell depletion targeting CD45RA enhances early T-cell recovery and can represent a salvage therapy. In this study, an immunocompromised non-transplanted patient with CMV disease and toxicity to conventional therapy was successfully treated by adoptive transfer of CD45RA-depleted T-cells.