Optimizing Concentrations of Concomitant Antiretrovirals by Reducing Etravirine Doses: Two Case Reports of Complex Drug-drug Interactions. Issue 1 (January 2019)

• Record Type: Journal Article
• Authors: Denault, Jean-Simon; Cabot, Jean-François; Langlois, Hugo; Marcotte, Suzanne; Sheehan, Nancy L
• Is Part Of: Antiviral therapy. Volume 24:Issue 1(2019)
• Page Start: 73
• Page End: 76
• Publication Date: 2019-01
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP3274
• Languages: English
• ISSNs: 1359-6535

Abstract

We report the cases of two treatment-experienced HIV-infected patients with complex antiretroviral regimens that showed significant drug–drug interactions with etravirine. Unexpectedly high etravirine concentrations likely caused subtherapeutic levels of darunavir, elvitegravir and dolutegravir through concentration-dependent metabolic induction. Therapeutic drug monitoring allowed safe etravirine dose decreases to manage these interactions.