HIV Viral Suppression in TREAT Asia HIV Observational Database Enrolled Adults on Antiretroviral Therapy at the Social Health Clinic, the National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia. Issue 8 (November 2016)

• Record Type: Journal Article
• Authors: Boettiger, David C; Khol, Vohith; Durier, Nicolas; Law, Matthew; Sun, Ly Penh
• Is Part Of: Antiviral therapy. Volume 21:Issue 8(2016)
• Page Start: 725
• Page End: 730
• Publication Date: 2016-11
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP3052
• Languages: English
• ISSNs: 1359-6535

Abstract

Background: The Social Health Clinic at the National Center for HIV/AIDS, Dermatology & STDs (SHC-NCHADS) in Phnom Penh is a major provider of antiretroviral therapy (ART) in Cambodia. However, patient access to viral load monitoring is uncommon. We conducted a cross-sectional evaluation of HIV viral load in SHC-NCHADS patients on ART to determine the proportion experiencing virological failure and to identify factors associated with virological failure in this population. Methods: Patients who had been using their current first-or second-line ART regimen for ≥6 months were eligible. Virological failure was defined as a viral load >1, 000 copies/ml, death, lost-to-follow-up or the absence of viral load testing despite presenting for care. Factors associated with virological failure were evaluated using logistic regression. Results: Overall, 463 patients (53.1% male, median age 42.1 years) were included in the investigation. At the time of current regimen initiation, median CD4 + T-cell count was 101 cells/mm 3 and 89.0% of patients had experienced a WHO stage III/IV event. At the time of testing/ last clinic visit, 28 (6.0%) patients met our definition of virological failure. Median viral load among those failing was 9, 633 copies/ml. Shorter time on current ART regimen, low CD4 + T-cell count at the time of viral load testing/last clinic visit and a record of suboptimal adherence were the strongest predictors of virological failure. Conclusions: This work demonstrates the high rate of viral suppression being achieved by the treatment programme at SHC-NCHADS and the need for future work to phase-in routine viral load monitoring in Cambodia.