Tenofovir Alafenamide as Part of a Salvage Regimen in a Patient with Multi-Drug Resistant HIV and Tenofovir-DF-Associated Renal Tubulopathy. Issue 6 (August 2016)

• Record Type: Journal Article
• Authors: Mikula, James M; Manion, Maura M; Maldarelli, Frank; Suarez, Lucila M; Norman-Wheeler, Jaha F; Ober, Alex G; Dewar, Robin L; Kopp, Jeffrey B; Lane, H Clifford; Pau, Alice K
• Is Part Of: Antiviral therapy. Volume 21:Issue 6(2016)
• Page Start: 553
• Page End: 558
• Publication Date: 2016-08
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP3040
• Languages: English
• ISSNs: 1359-6535

Abstract

We describe a patient with two recent episodes of tenofovir disoproxil fumarate (TDF)-associated acute kidney injury and six-class drug-resistant HIV infection who achieved and maintained viral suppression without worsening kidney function on a regimen including tenofovir alafenamide (TAF) through 48 weeks of therapy. The safety and efficacy of TAF in patients with TDF-associated renal tubulopathy and multiple drug resistant HIV has not yet been described. TAF may represent a useful option to maximally suppress HIV in patients with these complications.