Cerebrospinal Fluid Viral Escape and Acute Encephalitis in a Patient on Boosted Protease Inhibitor Monotherapy. Issue 5 (July 2016)

• Record Type: Journal Article
• Authors: Tiraboschi, Juan; Hamzah, Lisa; Siddiqui, Ata; Kulasegaram, Ranjababu; Post, Frank; Fox, Julie
• Is Part Of: Antiviral therapy. Volume 21:Issue 5(2016)
• Page Start: 461
• Page End: 464
• Publication Date: 2016-07
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP3021
• Languages: English
• ISSNs: 1359-6535

Abstract

Although currently available data suffice to support the use of protease inhibitor monotherapy in selected patients, there is concern about the antiviral activity of this regimen in the long term and in viral sanctuaries, such as the central nervous system. We report a case of encephalitis related to viral escape while receiving darunavir/ritonavir monotherapy in a carefully selected patient for participation in a clinical trial.