Successful Treatment with Sofosbuvir of Fibrosing Cholestatic Hepatitis C after Liver Transplantation in an HIV–HCV-Coinfected Patient. Issue 3 (April 2015)

• Record Type: Journal Article
• Authors: Borentain, Patrick; Colson, Philippe; Dhiver, Catherine; Gregoire, Emilie; Hardwigsen, Jean; Botta-Fridlund, Danielle; Garcia, Stéphane; Gerolami, René
• Is Part Of: Antiviral therapy. Volume 20:Issue 3(2015)
• Page Start: 353
• Page End: 356
• Publication Date: 2015-04
• Subjects: Antiviral agents -- Periodicals; Antiviral Agents -- therapeutic use; Virus Diseases -- therapy; Viruses -- drug effects; Antiviral agents; Periodical; Electronic journals; Periodicals; 616.9106
• DOI: 10.3851/IMP2841
• Languages: English
• ISSNs: 1359-6535

Abstract

Fibrosing cholestatic hepatitis is a severe form of post-liver transplantation HCV recurrence. Fibrosing cholestatic hepatitis is characterized by its early onset and severe prognosis in HIV-infected patients. We report the case of an HIV–HCV genotype-4 coinfected patient successfully treated with a combination of sofosbuvir and ribavirin. After 4 weeks of treatment we observed a resolution of HCV recurrence related symptoms associated with a normalization of liver biochemistry and dramatic decrease of HCV viral load. This case illustrates the efficiency and tolerance of a sofosbuvir-based anti-HCV interferon-free regimen in post-liver HCV recurrence. Because of the absence of drug interactions between sofosbuvir and antiretroviral treatment or calcineurin inhibitors, its administration in HIV–HCV-coinfected liver transplanted patients is very promising.