[123I]FP-CIT SPECT in atypical degenerative parkinsonism. (August 2012)

• Record Type: Journal Article
• Authors: Isaias, Ioannis U; Marotta, Giorgio; Pezzoli, Gianni; Sabri, Osama; Hesse, Swen
• Is Part Of: Imaging in medicine. Volume 4:Number 4(2012)
• Page Start: 411
• Page End: 421
• Publication Date: 2012-08
• Subjects: atypical degenerative parkinsonism -- FP-CIT -- ioflupane -- SPECT; Diagnostic imaging -- Periodicals; 616.075405
• DOI: 10.2217/iim.12.21
• Languages: English
• ISSNs: 1755-5205

Abstract

One of the most widely used techniques to support the clinical diagnosis of Parkinson's disease is the SPECT scan with [ 123 I]FP-CIT. This tracer binds reversibly and visualizes the striatal presynaptic dopamine transporters. Several uncertainties remain on the value of [ 123 I]FP-CIT and SPECT in atypical degenerative parkinsonian syndromes. In this concise review, we discuss the contribution of SPECT and [ 123 I]FP-CIT in supporting the clinical diagnosis of Parkinson's disease and their role in the differential diagnosis of Parkinson's disease and atypical degenerative parkinsonism. The chemistry, pharmacodynamics and pharmacokinetics of [ 123 I]FP-CIT are also discussed.