Using contrast agents to obtain maps of regional perfusion and capillary wall permeability. (August 2012)

• Record Type: Journal Article
• Authors: Wirestam, Ronnie
• Is Part Of: Imaging in medicine. Volume 4:Number 4(2012)
• Page Start: 423
• Page End: 442
• Publication Date: 2012-08
• Subjects: capillary wall permeability -- contrast agent -- dynamic studies -- medical imaging -- perfusion -- tissue blood flow -- tracer kinetics; Diagnostic imaging -- Periodicals; 616.075405
• DOI: 10.2217/iim.12.24
• Languages: English
• ISSNs: 1755-5205

Abstract

Tracer kinetic modeling for quantification of perfusion and capillary wall permeability is a well-established approach, applied to various imaging modalities. In this review, methods employing intravascular as well as diffusible nonradioactive contrast agents for characterization of tissue microcirculation and microvasculature are described. The article focuses on perfusion and permeability imaging by MRI, particularly for brain applications, and the use of alternative medical imaging methods, such as CT and ultrasound, is also briefly introduced.