Natural products from anaerobes. (1st March 2019)

• Record Type: Journal Article
• Authors: Li, Jeffrey S; Barber, Colin Charles; Zhang, Wenjun
• Is Part Of: Journal of industrial microbiology & biotechnology. Volume 46:Number 3/4(2019)
• Page Start: 375
• Page End: 383
• Publication Date: 2019-03-01
• Subjects: Secondary metabolite -- Anaerobic organism -- Genome mining -- Antibiotic; Industrial microbiology -- Periodicals; 660.62
• DOI: 10.1007/s10295-018-2086-5
• Languages: English
• ISSNs: 1367-5435

Abstract

Abstract: Natural product discovery in the microbial world has historically been biased toward aerobes. Recent in silico analysis demonstrates that genomes of anaerobes encode unexpected biosynthetic potential for natural products, however, chemical data on natural products from the anaerobic world are extremely limited. Here, we review the current body of work on natural products isolated from strictly anaerobic microbes, including recent genome mining efforts to discover polyketides and non-ribosomal peptides from anaerobes. These known natural products of anaerobes have demonstrated interesting molecular scaffolds, biosynthetic logic, and/or biological activities, making anaerobes a promising reservoir for future natural product discovery.