Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics. (1st May 2017)

• Record Type: Journal Article
• Authors: Bandyopadhyay, Arpan A; Khetan, Anurag; Malmberg, Li-Hong; Zhou, Weichang; Hu, Wei-Shou
• Is Part Of: Journal of industrial microbiology & biotechnology. Volume 44:Number 4/5(2017)
• Page Start: 785
• Page End: 797
• Publication Date: 2017-05-01
• Subjects: Natural products -- Protein biologics -- Process technology; Industrial microbiology -- Periodicals; 660.62
• DOI: 10.1007/s10295-017-1913-4
• Languages: English
• ISSNs: 1367-5435

Abstract

Abstract: The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.